GSK232 | CAS#2702984-69-6 | CECR2 Inhibitor

MedKoo Cat#: 534631 | Name: GSK232

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK232 is a novel highly selective, cellularly penetrant CECR2 inhibitor with excellent physicochemical properties.

Chemical Structure

GSK232

CAS#2702984-69-6 (free base)

Theoretical Analysis

MedKoo Cat#: 534631

Name: GSK232

CAS#: 2702984-69-6 (free base)

Chemical Formula: C21H27ClN6O3S

Exact Mass: 478.1554

Molecular Weight: 479.00

Elemental Analysis: C, 52.66; H, 5.68; Cl, 7.40; N, 17.55; O, 10.02; S, 6.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

GSK232 HCl 2702984-69-6 (free base) 2702984-66-3 (S-isomer)

Synonym

GSK232; GSK-232; GSK 232

IUPAC/Chemical Name

(R)-N-(4-Chloro-3-((3-cyclopropylpyrrolidin-1-yl)sulfonyl)phenyl)-2-(5-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridin-1-yl)acetamide

InChi Key

DBLNLPCEKQBLAI-HNNXBMFYSA-N

InChi Code

InChI=1S/C21H27ClN6O3S/c1-26-8-7-19-18(12-26)24-25-28(19)13-21(29)23-16-4-5-17(22)20(10-16)32(30,31)27-9-6-15(11-27)14-2-3-14/h4-5,10,14-15H,2-3,6-9,11-13H2,1H3,(H,23,29)/t15-/m0/s1

SMILES Code

O=C(NC1=CC=C(Cl)C(S(=O)(N2C[C@@H](C3CC3)CC2)=O)=C1)CN4N=NC5=C4CCN(C)C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 479.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lucas SCC, Atkinson SJ, Bamborough P, Barnett H, Chung CW, Gordon L, Mitchell DJ, Phillipou A, Prinjha RK, Sheppard RJ, Tomkinson NCO, Watson RJ, Demont EH. Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. J Med Chem. 2020 May 6. doi: 10.1021/acs.jmedchem.0c00021. Epub ahead of print. PMID: 32321240.