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MedKoo Cat#: 593193 | Name: GSK232 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK232 is a a highly selective, cellularly penetrant CECR2 inhibitor with excellent physicochemical properties.

Chemical Structure

GSK232 HCl
GSK232 HCl
CAS#GSK232 HCl

Theoretical Analysis

MedKoo Cat#: 593193

Name: GSK232 HCl

CAS#: GSK232 HCl

Chemical Formula: C21H28Cl2N6O3S

Exact Mass: 478.1554

Molecular Weight: 515.45

Elemental Analysis: C, 48.93; H, 5.48; Cl, 13.75; N, 16.30; O, 9.31; S, 6.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
GSK232 HCl 2702984-69-6 (free base) 2702984-66-3 (S-isomer)
Synonym
GSK232; GSK-232; GSK 232; GSK232 HCl
IUPAC/Chemical Name
(R)-N-(4-chloro-3-((3-cyclopropylpyrrolidin-1-yl)sulfonyl)phenyl)-2-(5-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridin-1-yl)acetamide hydrochloride
InChi Key
FFTGSUAZXIOWBM-RSAXXLAASA-N
InChi Code
InChI=1S/C21H27ClN6O3S.ClH/c1-26-8-7-19-18(12-26)24-25-28(19)13-21(29)23-16-4-5-17(22)20(10-16)32(30,31)27-9-6-15(11-27)14-2-3-14;/h4-5,10,14-15H,2-3,6-9,11-13H2,1H3,(H,23,29);1H/t15-;/m0./s1
SMILES Code
O=C(NC1=CC=C(Cl)C(S(=O)(N2C[C@@H](C3CC3)CC2)=O)=C1)CN4N=NC5=C4CCN(C)C5.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lucas SCC, Atkinson SJ, Bamborough P, Barnett H, Chung CW, Gordon L, Mitchell DJ, Phillipou A, Prinjha RK, Sheppard RJ, Tomkinson NCO, Watson RJ, Demont EH. Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. J Med Chem. 2020 May 6. doi: 10.1021/acs.jmedchem.0c00021. [Epub ahead of print] PubMed PMID: 32321240.