MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 593178 | Name: BMS-986251

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-986251 is a Clinically Viable, Potent, and Selective RORγt Inverse Agonist. BMS-986251 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model. BMS-986251 was studied in mouse acanthosis and imiquimod-induced models of skin inflammation, where it demonstrated robust efficacy comparable to a positive control.

Chemical Structure

BMS-986251
CAS#2041841-30-7

Theoretical Analysis

MedKoo Cat#: 593178

Name: BMS-986251

CAS#: 2041841-30-7

Chemical Formula: C30H29F8NO5S

Exact Mass: 667.1639

Molecular Weight: 667.61

Elemental Analysis: C, 53.97; H, 4.38; F, 22.77; N, 2.10; O, 11.98; S, 4.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
2041841-30-7 2460133-35-9
Synonym
BMS986251; BMS-986251; BMS 986251
IUPAC/Chemical Name
(1R,3S,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)- 2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid
InChi Key
JQORWGARJVSRBA-QOTTZFGFSA-N
InChi Code
InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18+,22+,24+,27+/m0/s1
SMILES Code
FC(C(F)(F)F)(C(F)(F)F)C1=CC2=C(C=C1)[C@@]3(S(=O)(C4=CC=C(F)C=C4)=O)[C@@](N(C([C@@H]5CC[C@@H](C(O)=O)C[C@@H]5C)=O)CC3)([H])CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 667.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist Robert J. Cherney*, Lyndon A. M. Cornelius, Anurag Srivastava, Carolyn A. Weigelt, David Marcoux, James J.-W. Duan, Qing Shi, Douglas G. Batt, Qingjie Liu, Shiuhang Yip, Dauh-Rurng Wu, Max Ruzanov, John Sack, Javed Khan, Jinhong Wang, Melissa Yarde, Mary Ellen Cvijic, Arvind Mathur, Sha Li, David Shuster, Purnima Khandelwal, Virna Borowski, Jenny Xie, Mary Obermeier, Aberra Fura, Kevin Stefanski, Georgia Cornelius, Joseph A. Tino, John E. Macor, Luisa Salter-Cid, Rex Denton, Qihong Zhao, Percy H. Carter, and T. G. Murali Dhar Cite this: ACS Med. Chem. Lett. 2020, 11, 6, 1221–1227