BC-DXI01 | CAS#130217-49-1 | AIMP2-DX2 suppressor

MedKoo Cat#: 593176 | Name: BC-DXI01

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BC-DXI01 is a synthetic compound that specifically reduces the cellular levels of AIMP2-DX2 through selective degradation of the AIMP2-DX2 mRNA transcript. It has been found that BC-DXI01-mediated cell death positively correlates with AIMP2-DX2 expression in lung cancer cell lines.

Chemical Structure

BC-DXI01

CAS#130217-49-1

Theoretical Analysis

MedKoo Cat#: 593176

Name: BC-DXI01

CAS#: 130217-49-1

Chemical Formula: 12H13NO5

Exact Mass: 251.0794

Molecular Weight: 251.24

Elemental Analysis: C, 57.37; H, 5.22; N, 5.58; O, 31.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BCDXI01; BC-DXI01; BC DXI01

IUPAC/Chemical Name

4-Carboxymalonanilic acid ethyl ester; Benzoic acid, 4-[(3-ethoxy-1,3-dioxopropyl)amino]-

InChi Key

CIIBCTSKJNXPLW-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H13NO5/c1-2-18-11(15)7-10(14)13-9-5-3-8(4-6-9)12(16)17/h3-6H,2,7H2,1H3,(H,13,14)(H,16,17)

SMILES Code

O=C(O)C1=CC=C(NC(CC(OCC)=O)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 251.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lee HS, Kim DG, Oh YS, Kwon NH, Lee JY, Kim D, Park SH, Song JH, Lee S, Han JM, Park BJ, Lee J, Kim S. Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression. Biochem J. 2013 Sep 15;454(3):411-6. doi:10.1042/BJ20130550. PubMed PMID: 23815603.