MedKoo Cat#: 593189 | Name: BC-DXI-843
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BC-DXI-843 is AIMP2-DX2 inhibitor. It as a promising lead for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.

Chemical Structure

BC-DXI-843
BC-DXI-843
CAS#2421117-98-6

Theoretical Analysis

MedKoo Cat#: 593189

Name: BC-DXI-843

CAS#: 2421117-98-6

Chemical Formula: C28H26N4O4S2

Exact Mass: 546.1395

Molecular Weight: 546.66

Elemental Analysis: C, 61.52; H, 4.79; N, 10.25; O, 11.71; S, 11.73

Price and Availability

Size Price Availability Quantity
50mg USD 650.00 2 Weeks
100mg USD 1,050.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,450.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,650.00 2 Weeks
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Related CAS #
No Data
Synonym
BCDXI843; BCDXI-843; BCDXI 843; BC-DXI-843; BC-DXI843; BC-DXI 843;
IUPAC/Chemical Name
(S)-3-(1H-Indol-3-yl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(4-methylphenylsulfonamido)propanamide
InChi Key
VLPGAOXBMXGNGM-VWLOTQADSA-N
InChi Code
InChI=1S/C28H26N4O4S2/c1-18-7-13-22(14-8-18)38(34,35)32-25(15-20-16-29-24-6-4-3-5-23(20)24)27(33)31-28-30-26(17-37-28)19-9-11-21(36-2)12-10-19/h3-14,16-17,25,29,32H,15H2,1-2H3,(H,30,31,33)/t25-/m0/s1
SMILES Code
O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)[C@@H](NS(=O)(C3=CC=C(C)C=C3)=O)CC4=CNC5=C4C=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 546.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Aneesh Sivaraman, Dae Gyu Kim, Deepak Bhattarai, Minkyoung Kim, Hwa Young Lee, Semi Lim, Jiwon Kong, Ja-il GooSeunghwan Shim, Seungbeom Lee, Young-Ger Suh,Yongseok Choi, Sunghoon Kim, Kyeong Lee. Synthesis and Structure–Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J. Med. Chem. 2020. doi: 10.1021/acs.jmedchem.9b01961.