Synonym
VPC-14228; VPC 14228; VPC14228;
IUPAC/Chemical Name
4-(4-Phenylthiazol-2-yl)morpholine
InChi Key
MRNNJVNMXOZEQC-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H14N2OS/c1-2-4-11(5-3-1)12-10-17-13(14-12)15-6-8-16-9-7-15/h1-5,10H,6-9H2
SMILES Code
N1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
246.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Pang, J. P., Shen, C., Zhou, W. F., Wang, Y. X., Shan, L. H., Chai, X., ... & Hou, T. J. (2022). Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays. Acta Pharmacologica Sinica, 43(1), 229-239.
Dehm, S., Rennie, P., Gewirth, D., & University of Minnesota Minneapolis United States. (2015). Development of a New Class of Drugs to Inhibit All Forms of Androgen Receptor in Castration Resistant Prostate Cancers.
Bhumireddy, A., Bandaru, N. R., Reddy, B. R., Gore, S. T., Mukherjee, S., Balasubramanian, W. R., ... & Samajdar, S. (2022). Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders. Bioorganic & medicinal chemistry letters, 55, 128448.
