IUPAC/Chemical Name
1-(3-Chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)-5-[methyl(prop-2-ynyl)amino]pyrazole-4-carbonitrile
InChi Key
IHHMUBRVTJMLQO-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H15ClN6/c1-3-7-20(2)15-11(9-17)10-18-22(15)14-13(16)12-6-4-5-8-21(12)19-14/h1,10H,4-8H2,2H3
SMILES Code
N#CC1=C(N(C)CC#C)N(C2=NN(CCCC3)C3=C2Cl)N=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Pyraclonil is a PPO inhibitor.
In vitro activity:
This study evaluated the effectiveness of nine post-emergence herbicides against E. indica. Pyraclonil was identified as highly effective in controlling the S and MHR E. indica populations.
Reference: J Agric Food Chem. 2020 Mar 4;68(9):2623-2630. https://pubmed.ncbi.nlm.nih.gov/32058714/
Preparing Stock Solutions
The following data is based on the
product
molecular weight
314.78
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Deng W, Yang Q, Chen Y, Yang M, Xia Z, Zhu J, Chen Y, Cai J, Yuan S. Cyhalofop-butyl and Glyphosate Multiple-Herbicide Resistance Evolved in an Eleusine indica Population Collected in Chinese Direct-Seeding Rice. J Agric Food Chem. 2020 Mar 4;68(9):2623-2630. doi: 10.1021/acs.jafc.9b07342. Epub 2020 Feb 25. PMID: 32058714.
In vitro protocol:
1. Deng W, Yang Q, Chen Y, Yang M, Xia Z, Zhu J, Chen Y, Cai J, Yuan S. Cyhalofop-butyl and Glyphosate Multiple-Herbicide Resistance Evolved in an Eleusine indica Population Collected in Chinese Direct-Seeding Rice. J Agric Food Chem. 2020 Mar 4;68(9):2623-2630. doi: 10.1021/acs.jafc.9b07342. Epub 2020 Feb 25. PMID: 32058714.
1: Li W, Hu J. Photodegradation of the novel herbicide pyraclonil in aqueous solution: Kinetics, identification of photoproducts, mechanism, and toxicity assessment. Environ Pollut. 2024 Sep 15;357:124381. doi: 10.1016/j.envpol.2024.124381. Epub 2024 Jun 19. PMID: 38906402.
2: Fujimura K, Shima A. Water properties and quality of the largest rice production region in Japan and their influence on the reproduction of zebrafish. Environ Sci Pollut Res Int. 2024 Mar;31(14):21857-21868. doi: 10.1007/s11356-024-32597-3. Epub 2024 Feb 24. PMID: 38400980.
3: Deng W, Li Y, Yao S, Wu J, Zhu A, Yang Q, Yuan S. Current status of cyhalofop-butyl and metamifop resistance and diversity of the ACCase gene mutations in Chinese sprangletop (Leptochloa chinensis) from China. Pestic Biochem Physiol. 2023 Dec;197:105648. doi: 10.1016/j.pestbp.2023.105648. Epub 2023 Oct 14. PMID: 38072523.
4: Cai X, Chen J, Wang X, Gao H, Xiang B, Dong L. Mefenacet resistance in multiple herbicide-resistant Echinochloa crus-galli L. populations. Pestic Biochem Physiol. 2022 Mar;182:105038. doi: 10.1016/j.pestbp.2022.105038. Epub 2022 Jan 21. PMID: 35249656.
5: Ueda K, Nagai T. Relative sensitivity of duckweed Lemna minor and six algae to seven herbicides. J Pestic Sci. 2021 Aug 20;46(3):267-273. doi: 10.1584/jpestics.D21-018. PMID: 34566460; PMCID: PMC8422251.
6: Chen Y, Li HW, Cong F, Lian YX. Metabolomics profiling for identification of potential biomarkers in chickens infected with avian leukosis virus subgroup J (ALV-J). Res Vet Sci. 2021 Oct;139:166-171. doi: 10.1016/j.rvsc.2021.07.026. Epub 2021 Jul 25. PMID: 34332419.
7: Deng W, Yang Q, Chen Y, Yang M, Xia Z, Zhu J, Chen Y, Cai J, Yuan S. Cyhalofop-butyl and Glyphosate Multiple-Herbicide Resistance Evolved in an Eleusine indica Population Collected in Chinese Direct-Seeding Rice. J Agric Food Chem. 2020 Mar 4;68(9):2623-2630. doi: 10.1021/acs.jafc.9b07342. Epub 2020 Feb 25. PMID: 32058714.
8: Sudo M, Goto Y, Iwama K, Hida Y. Herbicide discharge from rice paddy fields by surface runoff and percolation flow: A case study in paddy fields in the Lake Biwa basin, Japan. J Pestic Sci. 2018 Feb 28;43(1):24-32. doi: 10.1584/jpestics.D17-061. PMID: 30363114; PMCID: PMC6140652.
