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MedKoo Cat#: 584528 | Name: KS 619-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KS 619-1 is isolated from Streptomyces californicus and inhibits Ca2+ and calmodulin cyclic nucleotide phosphodiesterase.

Chemical Structure

KS 619-1
KS 619-1
CAS#103370-21-4

Theoretical Analysis

MedKoo Cat#: 584528

Name: KS 619-1

CAS#: 103370-21-4

Chemical Formula: C26H18O9

Exact Mass: 474.0951

Molecular Weight: 474.42

Elemental Analysis: C, 65.82; H, 3.82; O, 30.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KS 619-1; KS-619-1
IUPAC/Chemical Name
Benzo(a)naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-8,13-dioxo-3-(2-oxopropyl)-
InChi Key
ODDJKDDLIBUZMH-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H18O9/c1-9(27)4-11-5-10-2-3-13-14(18(10)24(32)19(11)26(34)35)8-16-21(23(13)31)25(33)20-15(22(16)30)6-12(28)7-17(20)29/h5-8,28-29,31-32H,2-4H2,1H3,(H,34,35)
SMILES Code
O=C(C1=C(CC(C)=O)C=C(CCC(C(O)=C2C(C3=C4C=C(O)C=C3O)=O)=C5C=C2C4=O)C5=C1O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 474.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matsuda Y, Kase H. KS-619-1, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Streptomyces californicus. J Antibiot (Tokyo). 1987 Aug;40(8):1104-10. PubMed PMID: 3680022. 2: Matsuda Y, Nakanishi S, Nagasawa K, Kase H. Inhibition by new anthraquinone compounds, K-259-2 and KS-619-1, of calmodulin-dependent cyclic nucleotide phosphodiesterase. Biochem Pharmacol. 1990 Mar 1;39(5):841-9. PubMed PMID: 2155616.