HC106A is a novel inhibitor of DosRST, inhibiting Mtb survival during hypoxia-induced NRP, directly targeting the sensor kinase heme, via a mechanism that is distinct from the oxidation and alkylation of heme previously observed with artemisinin (HC101A).
MedKoo Cat#: 533426
Name: HC106A
CAS#: N/A
Chemical Formula: C10H7Cl2N3O2
Exact Mass: 270.9915
Molecular Weight: 272.09
Elemental Analysis: C, 44.14; H, 2.59; Cl, 26.06; N, 15.44; O, 11.76
The following data is based on the product molecular weight 272.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
