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MedKoo Cat#: 562653 | Name: VU0453379

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0453379 is a CNS-penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).

Chemical Structure

VU0453379
VU0453379
CAS#1638646-27-1 (free base)

Theoretical Analysis

MedKoo Cat#: 562653

Name: VU0453379

CAS#: 1638646-27-1 (free base)

Chemical Formula: C26H34N4O2

Exact Mass: 434.2682

Molecular Weight: 434.58

Elemental Analysis: C, 71.86; H, 7.89; N, 12.89; O, 7.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
VU0453379 HCl 1638646-27-1 (free base)
Synonym
VU0453379; VU-0453379; VU 0453379;
IUPAC/Chemical Name
(S)-2-Cyclopentyl-9-methyl-1-oxo-2,9-dihydro-1H-b-carboline-4-carboxylic acid (1-isopropyl-pyrrolidin-2-ylmethyl)-amide
InChi Key
OEYYOVRNPJSWTO-IBGZPJMESA-N
InChi Code
InChI=1S/C26H34N4O2/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t19-/m0/s1
SMILES Code
O=C(C(C1=C2N(C)C3=C1C=CC=C3)=CN(C4CCCC4)C2=O)NC[C@H]5N(C(C)C)CCC5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-py rrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7. doi: 10.1021/jm501375c. Epub 2014 Dec 2. PubMed PMID: 25423411; PubMed Central PMCID: PMC4266362.

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Frubiase

Frubiase