VU0453379 HCl | GLP-1R modulator

MedKoo Cat#: 127912 | Name: VU0453379 HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0453379 is a CNS-penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).

Chemical Structure

VU0453379 HCl

CAS#VU0453379 HCl

Theoretical Analysis

MedKoo Cat#: 127912

Name: VU0453379 HCl

CAS#: VU0453379 HCl

Chemical Formula: C26H35ClN4O2

Exact Mass: 0.0000

Molecular Weight: 471.04

Elemental Analysis: C, 66.30; H, 7.49; Cl, 7.53; N, 11.89; O, 6.79

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 750.00	2 Weeks
10mg	USD 1,050.00	2 Weeks

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Related CAS #

VU0453379 HCl 1638646-27-1 (free base)

Synonym

VU0453379 HCl; VU0453379 (hydrochloride); VU0453379; VU-0453379; VU 0453379;

IUPAC/Chemical Name

(S)-2-cyclopentyl-N-((1-isopropylpyrrolidin-2-yl)methyl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrido[3,4-b]indole-4-carboxamide hydrochloride

InChi Key

OCMGNMGYQPPMFF-FYZYNONXSA-N

InChi Code

InChI=1S/C26H34N4O2.ClH/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3;/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31);1H/t19-;/m0./s1

SMILES Code

O=C(C(C(C1=CC=CC=C12)=C3N2C)=CN(C4CCCC4)C3=O)NC[C@@H]5CCCN5C(C)C.Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 471.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-py rrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7. doi: 10.1021/jm501375c. Epub 2014 Dec 2. PubMed PMID: 25423411; PubMed Central PMCID: PMC4266362.