MedKoo Cat#: 593143 | Name: IU1-248
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

IU1-248 is an USP14 inhibitor. IU1-248 is 10-fold more potent than IU1.

Chemical Structure

IU1-248
IU1-248
CAS#2307472-03-1

Theoretical Analysis

MedKoo Cat#: 593143

Name: IU1-248

CAS#: 2307472-03-1

Chemical Formula: C20H23N3O2

Exact Mass: 337.1790

Molecular Weight: 337.42

Elemental Analysis: C, 71.19; H, 6.87; N, 12.45; O, 9.48

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
IU1-248; IU 1248; IU1248
IUPAC/Chemical Name
Benzonitrile, 4-​[3-​[2-​(4-​hydroxy-​1-​piperidinyl)​acetyl]​-​2,​5-​dimethyl-​1H-​pyrrol-​1-​yl]​-
InChi Key
WFOUOZGIXDMUJU-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H23N3O2/c1-14-11-19(20(25)13-22-9-7-18(24)8-10-22)15(2)23(14)17-5-3-16(12-21)4-6-17/h3-6,11,18,24H,7-10,13H2,1-2H3
SMILES Code
CC1=CC(C(CN2CCC(O)CC2)=O)=C(C)N1C3=CC=C(C#N)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 337.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Nathan J. SchauerRobert S. MaginXiaoxi LiuLaura M. DohertySara J. Buhrlage* Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. Journal of Medicinal Chemistry, Articles ASAP (Perspective). Publication Date (Web):November 4, 2019DOI: 10.1021/acs.jmedchem.9b01138 2. Wang Y, Jiang Y, Ding S, Li J, Song N, Ren Y, Hong D, Wu C, Li B, Wang F, He W, Wang J, Mei Z. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194. doi: 10.1038/s41422-018-0091-x. Epub 2018 Sep 25. PubMed PMID: 30254335; PubMed Central PMCID: PMC6274642.