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MedKoo Cat#: 130067 | Name: Zelasudil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zelasudil is a Rho-associated protein kinase (ROCK) inhibitor.

Chemical Structure

Zelasudil
Zelasudil
CAS#2365193-22-0

Theoretical Analysis

MedKoo Cat#: 130067

Name: Zelasudil

CAS#: 2365193-22-0

Chemical Formula: C22H21F2N7O

Exact Mass: 437.1776

Molecular Weight: 437.45

Elemental Analysis: C, 60.40; H, 4.84; F, 8.69; N, 22.41; O, 3.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Zelasudil
IUPAC/Chemical Name
4-{5-[(4-cyclopropyl-1H-indazol-5-yl)amino]-1-methyl-1H-1,2,4-triazol-3-yl}-N-(2,2-difluoroethyl)benzamide
InChi Key
HSZPZEGJQCFGDE-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H21F2N7O/c1-31-22(27-17-9-8-16-15(10-26-29-16)19(17)12-2-3-12)28-20(30-31)13-4-6-14(7-5-13)21(32)25-11-18(23)24/h4-10,12,18H,2-3,11H2,1H3,(H,25,32)(H,26,29)(H,27,28,30)
SMILES Code
O=C(NCC(F)F)C1=CC=C(C2=NN(C)C(NC3=C(C4CC4)C5=C(NN=C5)C=C3)=N2)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
ROCKs play a role in actin skeleton organization, cell adhesion and motility, proliferation, apoptosis, and remodeling of the ECM. ROCK inhibitors may be used as potential treatments for cardiovascular diseases, as well as to treat cancer, asthma, glaucoma, etc.

Preparing Stock Solutions

The following data is based on the product molecular weight 437.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL