Imidocarb propionate | CAS# 55750-06-6 | Antiprotozoal

MedKoo Cat#: 574144 | Name: Imidocarb propionate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imidocarb propionate is an antiprotozoal agent that eliminates blood parasites. Formulations containing imidocarb have been used in the veterinary treatment of babesiosis and other protozoal infections.

Chemical Structure

Imidocarb propionate

CAS#55750-06-6 (propionate)

Theoretical Analysis

MedKoo Cat#: 574144

Name: Imidocarb propionate

CAS#: 55750-06-6 (propionate)

Chemical Formula: C25H32N6O5

Exact Mass:

Molecular Weight: 496.57

Elemental Analysis: C, 60.47; H, 6.50; N, 16.92; O, 16.11

Price and Availability

Size	Price	Availability
1g	USD 250.00	2 Weeks
5g	USD 550.00	2 Weeks
10g	USD 950.00	2 Weeks

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Related CAS #

5318-76-3 (HCl) 55750-06-6 (propionate) 27885-92-3 (free base)

Synonym

Imidocarb propionate

IUPAC/Chemical Name

N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea, dipropanoate

InChi Key

AFGQXWSHYUHHNV-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H20N6O.2C3H6O2/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18;2*1-2-3(4)5/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26);2*2H2,1H3,(H,4,5)

SMILES Code

O=C(NC1=CC=CC(C2=NCCN2)=C1)NC3=CC(C4=NCCN4)=CC=C3.OC(CC)=O.OC(CC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC50 of 87 μg/mL.

In vitro activity:

TBD

In vivo activity:

These findings establish that imidocarb dipropionate treatment clears B. caballi infection with confirmation of lack of transmission risk either by direct blood transfer or a high tick burden. Reference: Antimicrob Agents Chemother. 2009 Oct;53(10):4327-32. https://pubmed.ncbi.nlm.nih.gov/19620328/

	Solvent	mg/mL	mM
Solubility
	DMF	1.0	2.01
	DMSO	16.8	33.85
	Ethanol	1.0	2.01
	PBS (pH 7.2)	10.0	20.14

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 496.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Schwint ON, Ueti MW, Palmer GH, Kappmeyer LS, Hines MT, Cordes RT, Knowles DP, Scoles GA. Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential. Antimicrob Agents Chemother. 2009 Oct;53(10):4327-32. doi: 10.1128/AAC.00404-09. Epub 2009 Jul 20. PMID: 19620328; PMCID: PMC2764191.

In vitro protocol:

TBD

In vivo protocol:

1. Mosqueda, J., Olvera-Ramírez, A., Aguilar-Tipacamú, G., et al. Current advances in detection and treatment of babesiosis. Curr. Med. Chem. 19(10), 1504-1518 (2012). 2. Rodriguez, R.I., and Trees, A.J. In vitro responsiveness of Babesia bovis to imidocarb dipropionate and the selection of a drug-adapted line. Vet. Parasitol. 62(1-2), 35-41 (1996). 3. Sevinc, F., Turgut, K., Sevinc, M., et al. Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs. Vet. Parasitol. 149(1-2), 65-71 (2007).