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MedKoo Cat#: 413658 | Name: Imidocarb HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imidocarb HCl is One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported.

Chemical Structure

Imidocarb HCl
Imidocarb HCl
CAS# 5318-76-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 413658

Name: Imidocarb HCl

CAS#: 5318-76-3 (HCl)

Chemical Formula: C19H22Cl2N6O

Exact Mass: 420.1232

Molecular Weight: 421.33

Elemental Analysis: C, 54.16; H, 5.26; Cl, 16.83; N, 19.95; O, 3.80

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Related CAS #
5318-76-3 (HCl) 55750-06-6 (propionate) 27885-92-3 (free base)
Synonym
Imidocarb HCl; NSC51189; NSC-51189; NSC 51189; Imidocarb hydrochloride; Imidocarb dihydrochloride
IUPAC/Chemical Name
1,3-Bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)urea dihydrochloride
InChi Key
MLRXMTYSQKIKAK-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N6O.2ClH/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18;;/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26);2*1H
SMILES Code
O=C(NC1=CC=CC(C2=NCCN2)=C1)NC3=CC=CC(C4=NCCN4)=C3.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baneth G. Antiprotozoal treatment of canine babesiosis. Vet Parasitol. 2018 Apr 30;254:58-63. doi: 10.1016/j.vetpar.2018.03.001. Epub 2018 Mar 7. PMID: 29657012. 2: Milnes EL, Delnatte P, Woodbury M, Hering A, Lee S, Smith DA, Nemeth NM, Gu Y, Gehring R, Johnson R. Pharmacokinetics of imidocarb dipropionate in white- tailed deer (Odocoileus virginianus) after single intramuscular administration. J Vet Pharmacol Ther. 2020 Jan;43(1):33-37. doi: 10.1111/jvp.12760. Epub 2019 Apr 1. PMID: 30933371. 3: Lehner AF, Hitron JA, May J, Hughes C, Eisenberg R, Schwint N, Knowles DP, Timoney P, Tobin T. Evaluation of mass spectrometric methods for detection of the anti-protozoal drug imidocarb. J Anal Toxicol. 2011 May;35(4):199-204. doi: 10.1093/anatox/35.4.199. PMID: 21513612. 4: Coldham NG, Moore AS, Dave M, Graham PJ, Sivapathasundaram S, Lake BG, Sauer MJ. Imidocarb residues in edible bovine tissues and in vitro assessment of imidocarb metabolism and cytotoxicity. Drug Metab Dispos. 1995 Apr;23(4):501-5. PMID: 7600919. 5: Su D, Li XB, Wang ZJ, Wang L, Wu WX, Xu JQ. Pharmacokinetics and bioavailability of imidocarb dipropionate in swine. J Vet Pharmacol Ther. 2007 Aug;30(4):366-70. doi: 10.1111/j.1365-2885.2007.00872.x. PMID: 17610411. 6: Belloli C, Lai OR, Ormas P, Zizzadoro C, Sasso G, Crescenzo G. Pharmacokinetics and mammary elimination of imidocarb in sheep and goats. J Dairy Sci. 2006 Jul;89(7):2465-72. doi: 10.3168/jds.S0022-0302(06)72320-7. PMID: 16772563. 7: Jaramillo FM, Piñeros DDV, Corrêa RR, Pogliani FC, Cogliati B, Baccarin RYA. Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses. Vet Rec Open. 2020 Nov 5;7(1):e000416. doi: 10.1136/vetreco-2020-000416. PMID: 33178437; PMCID: PMC7646365. 8: Moore AS, Coldham NG, Sauer MJ. A cellular mechanism for imidocarb retention in edible bovine tissues. Toxicol Lett. 1996 Oct;87(2-3):61-8. doi: 10.1016/0378-4274(96)03705-8. PMID: 8914612. 9: Price JE, Dolan TT. A comparison of the efficacy of imidocarb dipropionate and tetracycline hydrochloride in the treatment of canine ehrlichiosis. Vet Rec. 1980 Sep 20;107(12):275-7. doi: 10.1136/vr.107.12.275. PMID: 7210420. 10: Hines SA, Ramsay JD, Kappmeyer LS, Lau AO, Ojo KK, Van Voorhis WC, Knowles DP, Mealey RH. Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor. Parasit Vectors. 2015 Jan 20;8:33. doi: 10.1186/s13071-014-0611-6. PMID: 25600252; PMCID: PMC4311422.