Synonym
Triflupromazine , Triflupromazine Hydrochloride; Triflupromazine HCl; MC 4703; Neoprin; Nivoman; NSC 14959; NSC 17473; Flumazin; Fluopromazine;
IUPAC/Chemical Name
N,N-dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine, monohydrochloride
InChi Key
FTNWXGFYRHWUKG-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
SMILES Code
FC(F)(F)C1=CC=C2SC3=CC=CC=C3N(CCCN(C)C)C2=C1.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
388.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Snyder, S.H., Greenberg, D., and Yamumura, H.I. Antischizophrenic drugs: Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects. J. Psychiatr. Res. 11, 91-95 (1974).
2. Tuomisto, J. A new modification for studying 5-HT uptake by blood platelets: A re-evaluation of tricyclic antidepressants as uptake inhibitors. J. Pharm. Pharmacol. 26(2), 92-100 (1974).
3. De Castro, S.L., Soeiro, M.N., and De Meirelles Mde, N. Trypanosoma cruzi: Effect of phenothiazines on the parasite and its interaction with host cells. Mem. Inst. Oswaldo Cruz 87(2), 209-215 (1992).
4. Dastidar, S.G., Debnath, S., Mazumdar, K., et al. Triflupromazine: A microbicide non-antibiotic compound. Acta Microbiol. Immuno. Hung. 51(1-2), 75-83 (2004).
