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MedKoo Cat#: 522542 | Name: GSK1997132B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK1997132B is a potent, metabolically stable and centrally penetrant PPARγ partial agonist.

Chemical Structure

GSK1997132B
GSK1997132B
CAS#1168138-37-1

Theoretical Analysis

MedKoo Cat#: 522542

Name: GSK1997132B

CAS#: 1168138-37-1

Chemical Formula: C24H22F2N4O

Exact Mass: 420.1762

Molecular Weight: 420.46

Elemental Analysis: C, 68.56; H, 5.27; F, 9.04; N, 13.33; O, 3.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
GSK 1997132B; GSK-1997132B; GSK1997132B; GSK1997132; GSK-1997132; GSK 1997132.
IUPAC/Chemical Name
(R)-1-((3,5-difluoropyridin-2-yl)methyl)-2-methyl-N-(1-phenylpropyl)-1H-benzo[d]imidazole-5-carboxamide
InChi Key
VYCNCLBUJAXONJ-HXUWFJFHSA-N
InChi Code
InChI=1S/C24H22F2N4O/c1-3-20(16-7-5-4-6-8-16)29-24(31)17-9-10-23-21(11-17)28-15(2)30(23)14-22-19(26)12-18(25)13-27-22/h4-13,20H,3,14H2,1-2H3,(H,29,31)/t20-/m1/s1
SMILES Code
O=C(C1=CC=C2N(CC3=NC=C(F)C=C3F)C(C)=NC2=C1)N[C@@H](C4=CC=CC=C4)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sime M, Allan AC, Chapman P, Fieldhouse C, Giblin GM, Healy MP, Lambert MH, Leesnitzer LM, Lewis A, Merrihew RV, Rutter RA, Sasse R, Shearer BG, Willson TM, Xu RX, Virley DJ. Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Erratum in: Bioorg Med Chem Lett. 2013 Feb 15;23(4):1143. Wilson, Timothy M [corrected to Willson, Timothy M]. PubMed PMID: 21798739.