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MedKoo Cat#: 128646 | Name: NB3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NB3 is a SARM1 inhibitor with IC50 = 180 nM.

Chemical Structure

NB3
NB3
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128646

Name: NB3

CAS#: N/A

Chemical Formula: C11H14F3N3O

Exact Mass: 261.1089

Molecular Weight: 261.25

Elemental Analysis: C, 50.57; H, 5.40; F, 21.82; N, 16.08; O, 6.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NB3; NB-3; NB 3
IUPAC/Chemical Name
(S)-1-methyl-1-(1-(pyridin-4-yl)ethyl)-3-(2,2,2-trifluoroethyl)urea
InChi Key
NRMCGEBVBUWHHL-QMMMGPOBSA-N
InChi Code
InChI=1S/C11H14F3N3O/c1-8(9-3-5-15-6-4-9)17(2)10(18)16-7-11(12,13)14/h3-6,8H,7H2,1-2H3,(H,16,18)/t8-/m0/s1
SMILES Code
O=C(NCC(F)(F)F)N(C)[C@H](C1=CC=NC=C1)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 261.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy Maude Giroud, Bernd Kuhn, Sandra Steiner, Paul Westwood, Mateusz Mendel, Anisha Mani, Emmanuel Pinard, Wolfgang Haap, Uwe Grether, Paola Caramenti, Didier Rombach, Claudio Zambaldo, Martin Ritter, Philipp Schmid, Claire Gasser, Nina Aregger, Nora Séchet, Andreas Topp, Matthew Bilyard, Alexia Malnight-Alvarez, Inken Plitzko, Manuel Hilbert, Sissy Kalayil, Dominique Burger, Claudia Bonardi, Wiebke Saal, Achi Haider, Matthias Beat Wittwer, Alessandro Brigo, Jörg Benz, and James Keaney Journal of Medicinal Chemistry Article ASAP DOI: 10.1021/acs.jmedchem.4c03127 2. Matthew Bratkowski, Thomas C. Burdett, Jean Danao, Xidao Wang, Prakhyat Mathur, Weijing Gu, Jennifer A. Beckstead, Santosh Talreja, Yu-San Yang, Gregory Danko, Jae Hong Park, Mary Walton, Sean P. Brown, Christopher M. Tegley, Prem Raj B. Joseph, Charles H. Reynolds, Shilpa Sambashivan, Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease, Neuron, Volume 110, Issue 22, 2022, Pages 3711-3726.e16, ISSN 0896-6273, https://doi.org/10.1016/j.neuron.2022.08.017. (https://www.sciencedirect.com/science/article/pii/S0896627322007498)