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MedKoo Cat#: 130431 | Name: IMMH002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IMMH002 is a modulator of S1P1/agonist of S1PR1, showing promise as a potential treatment of psoriasis and idiopathic pulmonary fibrosis.

Chemical Structure

IMMH002
IMMH002
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130431

Name: IMMH002

CAS#: N/A

Chemical Formula: C22H26N2O3

Exact Mass: 366.1943

Molecular Weight: 366.46

Elemental Analysis: C, 72.11; H, 7.15; N, 7.64; O, 13.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
IMMH002; IMMH 002; IMMH-002
IUPAC/Chemical Name
2-amino-2-(2-(4'-(2-ethyloxazol-4-yl)-[1,1'-biphenyl]-4-yl)ethyl)propane-1,3-diol
InChi Key
ZCKUKNLXYYMSBU-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H26N2O3/c1-2-21-24-20(13-27-21)19-9-7-18(8-10-19)17-5-3-16(4-6-17)11-12-22(23,14-25)15-26/h3-10,13,25-26H,2,11-12,14-15,23H2,1H3
SMILES Code
OCC(CCC1=CC=C(C2=CC=C(C3=COC(CC)=N3)C=C2)C=C1)(N)CO
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 366.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jin J, Xue N, Liu Y, Fu R, Wang M, Ji M, Lai F, Hu J, Wang X, Xiao Q, Zhang X, Yin D, Bai L, Chen X, Rao S. A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models. Acta Pharm Sin B. 2020 Feb;10(2):276-288. doi: 10.1016/j.apsb.2019.11.006. Epub 2019 Nov 14. PMID: 32082973; PMCID: PMC7016294. 2: Xiao Q, Hu M, Chen S, Jin J, Li L, Hu J, Xie P, Yin D. S1P1-selective agonist prodrug IMMH002 is phosphorylated in rats to form an S-configured enantiomer: Synthesis, verification, and biological activity of the in vivo active metabolite. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127141. doi: 10.1016/j.bmcl.2020.127141. Epub 2020 Mar 26. PMID: 32249117. 3: Xiao Q, Hu M, Chen S, Tang Y, Shi Z, Jin J, Hu J, Xie P, Yin D. Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates. Acta Pharm Sin B. 2020 Jun;10(6):1134-1142. doi: 10.1016/j.apsb.2019.11.005. Epub 2019 Nov 15. PMID: 32642418; PMCID: PMC7332640. 4: Hao M, Fu R, Tai J, Tian Z, Yuan X, Chen Y, Wang M, Jiang H, Ji M, Lai F, Xue N, Bai L, Zhu Y, Lv X, Chen X, Jin J. S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung. Acta Pharm Sin B. 2023 Mar;13(3):1110-1127. doi: 10.1016/j.apsb.2022.10.006. Epub 2022 Oct 12. PMID: 36970190; PMCID: PMC10031262.