(−)-Bicuculline methochloride is an enantiomer of the GABA antagonist (+)-bicuculline methochloride. It increases the firing rate in rat cortical neurons similar to the (+) isomer but lacks GABA antagonist activity. (–)-Bicuculline methochloride inhibits sodium-independent GABA receptor binding with an IC50 value of 500 μM, which is approximately 100-fold less potent than (+)-bicuculline methochloride, but there is no stereoselectivity for sodium-dependent GABA receptor binding.
-Bicuculline methochloride3126.jpg "(−)-Bicuculline methochloride")
MedKoo Cat#: 574050
Name: (−)-Bicuculline methochloride
CAS#: 53552-05-9 (methochloride)
Chemical Formula: C21H20ClNO6
Exact Mass: 0.0000
Molecular Weight: 417.84
Elemental Analysis: C, 60.37; H, 4.82; Cl, 8.48; N, 3.35; O, 22.97
The following data is based on the product molecular weight 417.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
