Bicuculline methiodide | CAS#40709-69-1 | GABA(A) receptor antagonist

MedKoo Cat#: 561192 | Name: Bicuculline methiodide

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bicuculline methiodide is a GABA(A) receptor antagonist. Bicuculline methiodide attenuates inflammation by inhibiting the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, and by increasing the production of the anti-inflammatory cytokine interleukin-10, both of which play important roles in the pathogenesis of sepsis.

Chemical Structure

Bicuculline methiodide

CAS#40709-69-1 (methiodide)

Theoretical Analysis

MedKoo Cat#: 561192

Name: Bicuculline methiodide

CAS#: 40709-69-1 (methiodide)

Chemical Formula: C21H20INO6

Exact Mass: 0.0000

Molecular Weight: 509.30

Elemental Analysis: C, 49.53; H, 3.96; I, 24.92; N, 2.75; O, 18.85

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 350.00	2 Weeks
50mg	USD 650.00	2 Weeks

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Related CAS #

485-49-4 (free) 40709-69-1 (methiodide) 53552-05-9 (methochloride)

Synonym

Bicuculline methiodide

IUPAC/Chemical Name

(S)-6,6-dimethyl-5-((R)-8-oxo-6,8-dihydro-[1,3]dioxolo[4,5-e]isobenzofuran-6-yl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide

InChi Key

HKJKCPKPSSVUHY-GRTNUQQKSA-M

InChi Code

InChI=1S/C21H20NO6.HI/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m0./s1

SMILES Code

C[N+]1(C)[C@H]([C@@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=CC(OCO6)=C6C=C5CC1.[I-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 509.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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