MedKoo Cat#: 585232 | Name: Suberosin
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Suberosin is a coumarin which has anti-inflammatory activity. Suberosin decreased the rise in intracellular Ca2+ concentration ([Ca2+]i) in PBMC stimulated with PHA.

Chemical Structure

Suberosin
Suberosin
CAS#581-31-7

Theoretical Analysis

MedKoo Cat#: 585232

Name: Suberosin

CAS#: 581-31-7

Chemical Formula: C15H16O3

Exact Mass: 244.1099

Molecular Weight: 244.29

Elemental Analysis: C, 73.75; H, 6.60; O, 19.65

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,150.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Suberosin
IUPAC/Chemical Name
2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-butenyl)- (9CI)
InChi Key
RSZDAYHEZSRVHS-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H16O3/c1-10(2)4-5-11-8-12-6-7-15(16)18-14(12)9-13(11)17-3/h4,6-9H,5H2,1-3H3
SMILES Code
O=C1C=CC2=CC(C/C=C(C)\C)=C(OC)C=C2O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 10.0 40.90
DMSO 3.0 12.30
Ethanol 10.0 40.90
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hamerski D, Matern U. Elicitor-induced biosynthesis of psoralens in Ammi majus L. suspension cultures. Microsomal conversion of demethylsuberosin into (+)marmesin and psoralen. Eur J Biochem. 1988 Jan 15;171(1-2):369-75. doi: 10.1111/j.1432-1033.1988.tb13800.x. PMID: 2828055. 2: Teng CM, Li HL, Wu TS, Huang SC, Huang TF. Antiplatelet actions of some coumarin compounds isolated from plant sources. Thromb Res. 1992 Jun 1;66(5):549-57. doi: 10.1016/0049-3848(92)90309-x. PMID: 1523611. 3: Kawaii S, Tomono Y, Ogawa K, Sugiura M, Yano M, Yoshizawa Y, Ito C, Furukawa H. Antiproliferative effect of isopentenylated coumarins on several cancer cell lines. Anticancer Res. 2001 May-Jun;21(3B):1905-11. PMID: 11497276. 4: Lin LC, Yang LL, Chou CJ. Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica. Phytochemistry. 2003 Feb;62(4):619-22. doi: 10.1016/s0031-9422(02)00519-8. PMID: 12560036. 5: el-Shafae AM, Ibrahim MA. Bioactive kaurane diterpenes and coumarins from Fortunella margarita. Pharmazie. 2003 Feb;58(2):143-7. PMID: 12641334. 6: Chen YC, Tsai WJ, Wu MH, Lin LC, Kuo YC. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-kappaB. Br J Pharmacol. 2007 Feb;150(3):298-312. doi: 10.1038/sj.bjp.0706987. Epub 2006 Dec 18. PMID: 17179947; PMCID: PMC2013892. 7: Bayet C, Fazio C, Darbour N, Berger O, Raad I, Chaboud A, Dumontet C, Guilet D. Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis. Phytother Res. 2007 Apr;21(4):386-90. doi: 10.1002/ptr.2081. PMID: 17236173. 8: Figueroa M, Rivero-Cruz I, Rivero-Cruz B, Bye R, Navarrete A, Mata R. Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. J Ethnopharmacol. 2007 Aug 15;113(1):125-31. doi: 10.1016/j.jep.2007.05.015. Epub 2007 May 18. PMID: 17582715. 9: Cazal Cde M, Domingues Vde C, Batalhão JR, Bueno OC, Filho ER, da Silva MF, Vieira PC, Fernandes JB. Isolation of xanthyletin, an inhibitor of ants' symbiotic fungus, by high-speed counter-current chromatography. J Chromatogr A. 2009 May 8;1216(19):4307-12. doi: 10.1016/j.chroma.2009.02.066. Epub 2009 Mar 3. PMID: 19296958. 10: Trusheva B, Todorov I, Ninova M, Najdenski H, Daneshmand A, Bankova V. Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis. Chem Cent J. 2010 Mar 29;4:8. doi: 10.1186/1752-153X-4-8. PMID: 20350297; PMCID: PMC2851693. 11: Zhao A, Yang X, Yang X, Wang W, Tao H. [GC-MS analysis of essential oil from root of Angelica dahurica cv. Qibaizhi]. Zhongguo Zhong Yao Za Zhi. 2011 Mar;36(5):603-7. Chinese. PMID: 21657081. 12: Boutabet K, Kebsa W, Alyane M, Lahouel M. Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin. Indian J Nephrol. 2011 Apr;21(2):101-6. doi: 10.4103/0971-4065.82131. PMID: 21769172; PMCID: PMC3132328. 13: Lacroix D, Prado S, Kamoga D, Kasenene J, Bodo B. Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark. J Nat Prod. 2011 Oct 28;74(10):2286-9. doi: 10.1021/np2004825. Epub 2011 Oct 10. PMID: 21985060. 14: Matejić JS, Dzamić AM, Ristić MS, Randelović VN, Marin PD. Essential oil composition of Cachrys cristata--a rare and endangered species in the flora of Serbia. Nat Prod Commun. 2012 Feb;7(2):235-6. PMID: 22474967. 15: Golfakhrabadi F, Abdollahi M, Ardakani MR, Saeidnia S, Akbarzadeh T, Ahmadabadi AN, Ebrahimi A, Yousefbeyk F, Hassanzadeh A, Khanavi M. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40. doi: 10.3109/13880209.2014.892140. Epub 2014 Jul 14. PMID: 25017518. 16: Sajjadi SE, Eskandarian AA, Shokoohinia Y, Yousefi HA, Mansourian M, Asgarian-Nasab H, Mohseni N. Antileishmanial activity of prenylated coumarins isolated from Ferulago angulata and Prangos asperula. Res Pharm Sci. 2016 Jul;11(4):324-31. doi: 10.4103/1735-5362.189314. PMID: 27651813; PMCID: PMC5022381. 17: Sajjadi SE, Pestechian N, Kazemi M, Mohaghegh MA, Hosseini-Safa A. Evaluation of the Antimalarial Effect of Ferulago angulata (Schlecht.) Boiss. Extract and Suberosin Epoxide Against Plasmodium berghei in Comparison with Chloroquine Using in-vivo Test. Iran J Pharm Res. 2016 Summer;15(3):515-521. PMID: 27980587; PMCID: PMC5149039. 18: Tavakoli S, Delnavazi MR, Hadjiaghaee R, Jafari-Nodooshan S, Khalighi- Sigaroodi F, Akhbari M, Hadjiakhoondi A, Yassa N. Bioactive coumarins from the roots and fruits of Ferulago trifida Boiss., an endemic species to Iran. Nat Prod Res. 2018 Nov;32(22):2724-2728. doi: 10.1080/14786419.2017.1375915. Epub 2017 Sep 27. PMID: 28954543. 19: Liao ZC, Jiang X, Tian WJ, Lin T, Chen HF. [Chemical constituents from root of Angelica decursiva]. Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(15):2999-3003. Chinese. doi: 10.19540/j.cnki.cjcmm.20170512.003. PMID: 29139270. 20: Karakaya S, Gözcü S, Güvenalp Z, Özbek H, Yuca H, Dursunoğlu B, Kazaz C, Kılıç CS. The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots. Pharm Biol. 2018 Dec;56(1):18-24. doi: 10.1080/13880209.2017.1414857. PMID: 29233045; PMCID: PMC6130714.