Synonym
SCH-32615; SCH 32615; SCH32615;
IUPAC/Chemical Name
((S)-1-((2-carboxyethyl)amino)-1-oxo-3-phenylpropan-2-yl)-L-phenylalanine
InChi Key
WOVRTBFSWOVRST-ROUUACIJSA-N
InChi Code
InChI=1S/C21H24N2O5/c24-19(25)11-12-22-20(26)17(13-15-7-3-1-4-8-15)23-18(21(27)28)14-16-9-5-2-6-10-16/h1-10,17-18,23H,11-14H2,(H,22,26)(H,24,25)(H,27,28)/t17-,18-/m0/s1
SMILES Code
O=C(CCNC([C@@H](N[C@@H](CC1=CC=CC=C1)C(O)=O)CC2=CC=CC=C2)=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
384.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Marin C, Chase TN. Effects of SCH 32615, an enkephalinase inhibitor, on D-1 and D-2 dopamine receptor-mediated behaviors. Neuropharmacology. 1995 Jun;34(6):677-82. PubMed PMID: 7566505.
2: Jayaram A, Singh P, Carp HM. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82(5):1283-7. PubMed PMID: 7741304.
3: Jayaram A, Singh P, Carp H. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80(5):944-8. PubMed PMID: 7726437.
4: Coombs DW, Colburn RW, DeLeo JA, Hoopes PJ, Rhodes CH, Twitchell BB. Acute toxicology of an enkephalinase inhibitor (SCH 32615) given intrathecally in the ewe. Anesth Analg. 1993 Jan;76(1):123-30. PubMed PMID: 8418713.
5: Giorgi O, Pibiri MG, Ongini E, Trampus M, Biggio G. The neutral endopeptidase-24.11 (enkephalinase) inhibitor, SCH 32615, increases dopamine metabolism in the nucleus accumbens of the rat. Eur J Pharmacol. 1991 Apr 17;196(2):137-42. PubMed PMID: 1874283.
6: Chipkin RE, Coffin VL. Analgesic and acute central nervous system side effects of the intravenously administered enkephalinase inhibitor SCH 32615. Pharmacol Biochem Behav. 1991 Jan;38(1):21-7. PubMed PMID: 2017447.
7: al-Rodhan N, Chipkin R, Yaksh TL. The antinociceptive effects of SCH-32615, a neutral endopeptidase (enkephalinase) inhibitor, microinjected into the periaqueductal, ventral medulla and amygdala. Brain Res. 1990 Jun 18;520(1-2):123-30. PubMed PMID: 2207626.
