MedKoo Cat#: 574042 | Name: A2AR agonist-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1). A2AR agonist-1 also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease.

Chemical Structure

A2AR agonist-1
A2AR agonist-1
CAS#41552-95-8

Theoretical Analysis

MedKoo Cat#: 574042

Name: A2AR agonist-1

CAS#: 41552-95-8

Chemical Formula: C20H22N6O4

Exact Mass: 410.1703

Molecular Weight: 410.43

Elemental Analysis: C, 58.53; H, 5.40; N, 20.48; O, 15.59

Price and Availability

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1mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
A2AR agonist-1, JMF 1907, JMF1907, JMF-1907
IUPAC/Chemical Name
N-[2-(1H-indol-3-yl)ethyl]-adenosine
InChi Key
QGCNEMXXKWZPHR-WVSUBDOOSA-N
InChi Code
InChI=1S/C20H22N6O4/c27-8-14-16(28)17(29)20(30-14)26-10-25-15-18(23-9-24-19(15)26)21-6-5-11-7-22-13-4-2-1-3-12(11)13/h1-4,7,9-10,14,16-17,20,22,27-29H,5-6,8H2,(H,21,23,24)/t14-,16-,17-,20-/m1/s1
SMILES Code
[H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NCCC4=CNC5=C4C=CC=C5)N=CN=C32
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mediero A, Wilder T, Shah L, Cronstein BN. Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis. FASEB J. 2018 Jul;32(7):3487-3501. doi: 10.1096/fj.201700217R. Epub 2018 Feb 2. PMID: 29394106; PMCID: PMC5998975. 2: Beggiato S, Tomasini MC, Borelli AC, Borroto-Escuela DO, Fuxe K, Antonelli T, Tanganelli S, Ferraro L. Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission. J Neurochem. 2016 Jul;138(2):254-64. doi: 10.1111/jnc.13652. Epub 2016 Jun 21. PMID: 27127992.