Synonym
Arecaidine but-2-ynyl ester (tosylate); Arecaidine but-2-ynyl ester tosylate
IUPAC/Chemical Name
N-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid but-2-ynyl ester tosylate
InChi Key
GKPXMGUNTQSFGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15NO2.C7H8O3S/c1-3-4-8-14-11(13)10-6-5-7-12(2)9-10;1-6-2-4-7(5-3-6)11(8,9)10/h6H,5,7-9H2,1-2H3;2-5H,1H3,(H,8,9,10)
SMILES Code
O=C(C1=CCCN(C)C1)OCC#CC.OS(=O)(C2=CC=C(C)C=C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
365.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhang C, Sun T, Zhou P, Zhu Q, Zhang L. Role of Muscarinic Acetylcholine Receptor-2 in the Cerebellar Cortex in Cardiovascular Modulation in Anaesthetized Rats. Neurochem Res. 2016 Apr;41(4):804-12. doi: 10.1007/s11064-015-1755-2. Epub 2015 Nov 2. PubMed PMID: 26526144.
2: Chiang PH, Yeh WC, Lee CT, Weng JY, Huang YY, Lien CC. M(1)-like muscarinic acetylcholine receptors regulate fast-spiking interneuron excitability in rat dentate gyrus. Neuroscience. 2010 Aug 11;169(1):39-51. doi: 10.1016/j.neuroscience.2010.04.051. Epub 2010 Apr 28. PubMed PMID: 20433901.
3: Gevaert T, Owsianik G, Hutchings G, Everaerts W, Nilius B, De Ridder D. Maturation of stretch-induced contractile activity and its muscarinic regulation in isolated whole bladder strips from rat. Neurourol Urodyn. 2010 Jun;29(5):789-96. doi: 10.1002/nau.20553. PubMed PMID: 18288706.
4: Yoon SY, Kwon YB, Kim HW, Roh DH, Seo HS, Han HJ, Beitz AJ, Lee JH. A spinal muscarinic M2 receptor-GABAergic disinhibition pathway that modulates peripheral inflammation in mice. Neuropharmacology. 2007 Oct;53(5):677-86. Epub 2007 Aug 2. PubMed PMID: 17765931.
5: Finney SM, Stewart LH, Gillespie JI. Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3- and M2-dependent components of a motor/sensory system. BJU Int. 2007 Sep;100(3):668-78. Epub 2007 Jul 12. PubMed PMID: 17627783.
6: Malomouzh AI, Mukhtarov MR, Nikolsky EE, Vyskočil F. Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism. J Neurochem. 2007 Sep;102(6):2110-2117. doi: 10.1111/j.1471-4159.2007.04696.x. Epub 2007 Jun 11. PubMed PMID: 17561934.
7: González A 3rd, Crittenden EL, García DM. Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill. BMC Neurosci. 2004 Jul 13;5:23. PubMed PMID: 15251036; PubMed Central PMCID: PMC499547.
8: Shi H, Yang B, Xu D, Wang H, Wang Z. Electrophysiological characterization of cardiac muscarinic acetylcholine receptors: different subtypes mediate different potassium currents. Cell Physiol Biochem. 2003;13(2):59-74. PubMed PMID: 12649591.
9: Naumenko NV, Malomuzh AI, Khairova RA, Zefirov AL, Urazaev AKh. [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):619-26. Russian. PubMed PMID: 12136730.
10: Liu J, Evans MS, Lee TJ. Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation. J Pharmacol Exp Ther. 2002 Jul;302(1):397-405. Erratum in: J Pharmacol Exp Ther 2002 Sep;302(3):1303. PubMed PMID: 12065743.
11: Liu J, Lee TJ. Mechanism of prejunctional muscarinic receptor-mediated inhibition of neurogenic vasodilation in cerebral arteries. Am J Physiol. 1999 Jan;276(1):H194-204. doi: 10.1152/ajpheart.1999.276.1.H194. PubMed PMID: 9887033.
