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MedKoo Cat#: 585148 | Name: Fluocortolone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.

Chemical Structure

Fluocortolone
Fluocortolone
CAS#152-97-6

Theoretical Analysis

MedKoo Cat#: 585148

Name: Fluocortolone

CAS#: 152-97-6

Chemical Formula: C22H29FO4

Exact Mass: 376.2050

Molecular Weight: 376.47

Elemental Analysis: C, 70.19; H, 7.76; F, 5.05; O, 17.00

Price and Availability

Size Price Availability Quantity
5mg USD 1,430.00 2 Weeks
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Related CAS #
152-97-6 1176-82-5 (acetate)
Synonym
Fluocortolone; Fluocortolon; Fluorcortolone; Fluocortolona; SH 742; SH742; SH-742
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
InChi Key
GAKMQHDJQHZUTJ-ULHLPKEOSA-N
InChi Code
InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1
SMILES Code
C[C@@]12[C@@H](C(CO)=O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cudina O, Brboric J, Vujic Z, Radulovic D, Vladimirov S. Determination of fluocortolone pivalate and fluocortolone hexanoate in suppositories using reverse-phase HPLC. Farmaco. 2000 Feb;55(2):125-7. PubMed PMID: 10782383. 2: Prokosch V, Thanos S. Visual outcome of patients following NAION after treatment with adjunctive fluocortolone. Restor Neurol Neurosci. 2014;32(3):381-9. doi: 10.3233/RNN-120292. PubMed PMID: 24225379. 3: Veraldi S, Schianchi R, Pontini P, Gorani A. The association of isoconazole-diflucortolone in the treatment of pediatric tinea corporis. J Dermatolog Treat. 2018 Mar;29(2):200-201. doi: 10.1080/09546634.2017.1360988. Epub 2017 Sep 19. PubMed PMID: 28753055. 4: Kircik LH. Clocortolone pivalate: a topical corticosteroid with a unique structure. J Drugs Dermatol. 2013 Feb;12(2):s3-4. PubMed PMID: 23377404. 5: Abdel-Salam FS, Mahmoud AA, Ammar HO, Elkheshen SA. Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. J Liposome Res. 2017 Mar;27(1):41-55. doi: 10.3109/08982104.2016.1149866. Epub 2016 Mar 9. PubMed PMID: 26956098. 6: Haviv R, Capua M, Amir J, Harel L. Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate: a case report & review of the literature. Pediatr Rheumatol Online J. 2014 Oct 10;12:46. doi: 10.1186/1546-0096-12-46. eCollection 2014. Review. PubMed PMID: 25328491; PubMed Central PMCID: PMC4200200. 7: Freshwater DG. Fluocortolone. Br J Dermatol. 1967 Dec;79(12):729. PubMed PMID: 6064946. 8: Born J, Zwick A, Roth G, Fehm-Wolfsdorf G, Fehm HL. Differential effects of hydrocortisone, fluocortolone, and aldosterone on nocturnal sleep in humans. Acta Endocrinol (Copenh). 1987 Sep;116(1):129-37. PubMed PMID: 3661052. 9: Gerhards E, Nieuweboer B, Schulz G, Gibian H. [Metabolism of 6 -fluor-16 -methylpregna-1,4-dien-ll ,21-diol-3,20-dion (fluocortolone) in man. Isolation of 6 -hydroxylated metabolites (alkyl-substituted steroids VII)]. Acta Endocrinol (Copenh). 1971 Sep;68(1):98-126. German. PubMed PMID: 5109849. 10: Menne T, Andersen KE. Allergic contact dermatitis from fluocortolone, flucocortolone pivalate and fluocortolone caproate. Contact Dermatitis. 1977 Dec;3(6):337-40. PubMed PMID: 606488. 11: Legler UF. Pharmacokinetics of fluocortolone in man. Eur J Clin Pharmacol. 1986;30(5):615-7. PubMed PMID: 3758149. 12: Flasch H, Hofferber E. [Penetration kinetics of fluocortolone from a new base for ointment and creme (author's transl)]. Arzneimittelforschung. 1980;30(4):652-6. German. PubMed PMID: 7190408. 13: Fabry H, Yawalkar SJ. A comparative multicentre trial of halometasone ointment and fluocortolone plus fluocortolone caproate ointment in the treatment of psoriasis. J Int Med Res. 1983;11 Suppl 1:26-30. PubMed PMID: 6339289. 14: Bianchi L, Hansel K, Antonelli E, Bellini V, Stingeni L. Contact allergy to isoconazole nitrate with unusual spreading over extensive regions. Contact Dermatitis. 2017 Apr;76(4):243-245. doi: 10.1111/cod.12688. PubMed PMID: 28317189. 15: Reckers R. [Clinical trial of fluocortin butylester in a double-blind contralateral comparison versus fluocortolone and hydrocortisone acetate (author's transl)]. Arzneimittelforschung. 1977;27(11a):2240-4. German. PubMed PMID: 341901. 16: Coors EA, von den Driesch P. Treatment of erythrodermic cutaneous T-cell lymphoma with intermittent chlorambucil and fluocortolone therapy. Br J Dermatol. 2000 Jul;143(1):127-31. PubMed PMID: 10886146. 17: Tüber U, Posern U, Bickel U, Matthes H, Voigt K. Fluocortolone: pharmacokinetics and effect on ACTH and cortisol secretion during daily and alternate-day administration. Eur J Clin Pharmacol. 1988;35(2):177-81. PubMed PMID: 2847930. 18: Lopatta F, Vecsei P, Täuber U, Haack D. [Pharmacokinetics of fluocortolone in long term therapy of patients with rheumatic and hematologic diseases]. Arzneimittelforschung. 1986 Aug;36(8):1268-71. German. PubMed PMID: 3490855. 19: Göçmen ES, Atalay Y, Evren Kemer Ö, Sarıkatipoğlu HY. Anterior Segment Ischemia after Strabismus Surgery. Turk J Ophthalmol. 2017 Jan;47(1):47-51. doi: 10.4274/tjo.93824. Epub 2017 Jan 17. PubMed PMID: 28182149; PubMed Central PMCID: PMC5282541. 20: Eroğlu İ, Azizoğlu E, Özyazıcı M, Nenni M, Gürer Orhan H, Özbal S, Tekmen I, Ertam İ, Ünal İ, Özer Ö. Effective topical delivery systems for corticosteroids: dermatological and histological evaluations. Drug Deliv. 2016 Jun;23(5):1502-13. doi: 10.3109/10717544.2014.960981. Epub 2014 Sep 26. PubMed PMID: 25259424.