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MedKoo Cat#: 530991 | Name: MDK-4624

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK-4624, also known as AMPKα1 activator C13, is a AMPKα1 activator. MDK-4624 has CAS#1243184-62-4. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 potently inhibits melanoma cell proliferation.

Chemical Structure

MDK-4624
MDK-4624
CAS#1243184-62-4

Theoretical Analysis

MedKoo Cat#: 530991

Name: MDK-4624

CAS#: 1243184-62-4

Chemical Formula: C17H22NO10P

Exact Mass: 431.0981

Molecular Weight: 431.33

Elemental Analysis: C, 47.34; H, 5.14; N, 3.25; O, 37.09; P, 7.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
MDK-4624; MDK4624; MDK 4624; AMPKα1 activator C13; C13, Compound 13.
IUPAC/Chemical Name
(((5-(5-oxo-4,5-dihydroisoxazol-3-yl)furan-2-yl)phosphoryl)bis(oxy))bis(methylene) bis(2-methylpropanoate)
InChi Key
NNMZZIPZHAKTQH-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H22NO10P/c1-10(2)16(20)23-8-25-29(22,26-9-24-17(21)11(3)4)15-6-5-13(27-15)12-7-14(19)28-18-12/h5-6,10-11H,7-9H2,1-4H3
SMILES Code
CC(C)C(OCOP(C1=CC=C(C(C2)=NOC2=O)O1)(OCOC(C(C)C)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou C, Gu J, Zhang G, Dong D, Yang Q, Chen MB, Xu D. AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity. Oncotarget. 2017 Feb 28;8(9):14736-14747. doi: 10.18632/oncotarget.14718. PubMed PMID: 28103582; PubMed Central PMCID: PMC5362439. 2: Guo S, Mao L, Ji F, Wang S, Xie Y, Fei H, Wang XD. Activating AMP-activated protein kinase by an α1 selective activator compound 13 attenuates dexamethasone-induced osteoblast cell death. Biochem Biophys Res Commun. 2016 Mar 18;471(4):545-52. doi: 10.1016/j.bbrc.2016.02.036. Epub 2016 Feb 15. PubMed PMID: 26891866. 3: Hu X, Jiang F, Bao Q, Qian H, Fang Q, Shao Z. Compound 13, an α1-selective small molecule activator of AMPK, potently inhibits melanoma cell proliferation. Tumour Biol. 2016 Jan;37(1):1071-8. doi: 10.1007/s13277-015-3854-8. Epub 2015 Aug 14. PubMed PMID: 26271666. 4: Zhao H, Zhu H, Lin Z, Lin G, Lv G. Compound 13, an α1-selective small molecule activator of AMPK, inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. Biochem Biophys Res Commun. 2015 Aug 7;463(4):510-7. doi: 10.1016/j.bbrc.2015.05.059. Epub 2015 May 27. PubMed PMID: 26022128.