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MedKoo Cat#: 585127 | Name: SX 3228

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SX 3228 is a selective ligand for the BZ1 receptor and potent hypnotic when given to the rat during the dark period of the light-dark cycle.

Chemical Structure

SX 3228
SX 3228
CAS#156364-04-4

Theoretical Analysis

MedKoo Cat#: 585127

Name: SX 3228

CAS#: 156364-04-4

Chemical Formula: C18H18N4O3

Exact Mass: 338.1379

Molecular Weight: 338.37

Elemental Analysis: C, 63.89; H, 5.36; N, 16.56; O, 14.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SX 3228; SX-3228; SX3228
IUPAC/Chemical Name
1,6-Naphthyridin-2(1H)-one, 5,6,7,8-tetrahydro-3-(5-methoxy-1,3,4-oxadiazol-2-yl)-6-(phenylmethyl)-
InChi Key
BZLLVTYOOJNQIF-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18N4O3/c1-24-18-21-20-17(25-18)14-9-13-11-22(8-7-15(13)19-16(14)23)10-12-5-3-2-4-6-12/h2-6,9H,7-8,10-11H2,1H3,(H,19,23)
SMILES Code
O=C1NC2=C(CN(CC3=CC=CC=C3)CC2)C=C1C4=NN=C(OC)O4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Alvariño F, Monti JM, Jantos H, Monti D. Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat. Braz J Med Biol Res. 1999 Aug;32(8):1007-14. PubMed PMID: 10454763. 2: Griebel G, Perrault G, Sanger DJ. Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents. J Psychopharmacol. 1998;12(4):356-65. PubMed PMID: 10065909. 3: Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ. Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands. Behav Pharmacol. 1999 Sep;10(5):483-95. PubMed PMID: 10780255. 4: Sanger DJ. The effects of new hypnotic drugs in rats trained to discriminate ethanol. Behav Pharmacol. 1997 Aug;8(4):287-92. PubMed PMID: 9832988. 5: Fujita M, Himi S, Handa T. Effects of compression and grinding on chemical stability of a benzodiazepine receptor agonist. Chem Pharm Bull (Tokyo). 2010 Jan;58(1):51-5. PubMed PMID: 20045966. 6: Fujita M, Himi S, Iwata M. Stabilization study on a wet-granule tableting method for a compression-sensitive benzodiazepine receptor agonist. Chem Pharm Bull (Tokyo). 2010 Mar;58(3):359-62. PubMed PMID: 20190441. 7: Ohta T. [Recent progress in development of psychotropic drugs (5)--Hypnotics]. Nihon Shinkei Seishin Yakurigaku Zasshi. 1996 Oct;16(5):161-70. Review. Japanese. PubMed PMID: 8962434.