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MedKoo Cat#: 573921 | Name: JM-244

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JM-244amine is a Pt(IV) dicarboxylates that may be useful in the study of carcinoma cell lines. JM-244 slows S-phase transit and blocks G2. Studies show cells die either through apoptosis (largely during S-phase) or by failing to overcome the G2 block (some days after treatment). In G2, the cells either divided or became enlarged and died.

Chemical Structure

JM-244
JM-244
CAS#129580-58-1

Theoretical Analysis

MedKoo Cat#: 573921

Name: JM-244

CAS#: 129580-58-1

Chemical Formula: C17H22Cl2N2O4Pt

Exact Mass: 583.0604

Molecular Weight: 584.36

Elemental Analysis: C, 34.94; H, 3.79; Cl, 12.13; N, 4.79; O, 10.95; Pt, 33.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JM 244, JM-244, JM244
IUPAC/Chemical Name
Platinum, amminebis(benzoato-O)dichloro(1-propanamine)-, (OC-6-43)-
InChi Key
CEIAKSIEJLYWAV-UHFFFAOYSA-J
InChi Code
1S/2C7H6O2.C3H9N.2ClH.H3N.Pt/c2*8-7(9)6-4-2-1-3-5-6;1-2-3-4;;;;/h2*1-5H,(H,8,9);2-4H2,1H3;2*1H;1H3;/q;;;;;;+4/p-4
SMILES Code
[Pt+4].NCCC.N.[ClH-].[ClH-].c1(ccccc1)C([O-])=O.c1(ccccc1)C([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 584.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ormerod MG, Orr RM, O'Neill CF, Chwalinski T, Titley JC, Kelland LR, Harrap KR. The cytotoxic action of four ammine/amine platinum(IV) dicarboxylates: a flow cytometric study. Br J Cancer. 1996 Dec;74(12):1935-43. PubMed PMID: 8980393; PubMed Central PMCID: PMC2074815. 2: Orr RM, O'Neill CF, Nicolson MC, Barnard CF, Murrer BA, Giandomenico CM, Vollano JF, Harrap KR. Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin. Br J Cancer. 1994 Sep;70(3):415-20. PubMed PMID: 8080724; PubMed Central PMCID: PMC2033379. 3: Kelland LR, Mistry P, Abel G, Loh SY, O'Neill CF, Murrer BA, Harrap KR. Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates. Cancer Res. 1992 Jul 15;52(14):3857-64. PubMed PMID: 1617660. 4: Kelland LR, Murrer BA, Abel G, Giandomenico CM, Mistry P, Harrap KR. Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 1992 Feb 15;52(4):822-8. PubMed PMID: 1737343.