MedKoo Cat#: 464882 | Name: UNC6641

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UNC6641 is a novel peptidomimetic antagonist of the PHF1 Tudor domain, binding both PHF1 Tudor domain and the related protein PHF19.

Chemical Structure

UNC6641
UNC6641
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464882

Name: UNC6641

CAS#: unknown

Chemical Formula: C49H86N14O8

Exact Mass: 998.6753

Molecular Weight: 999.32

Elemental Analysis: C, 58.89; H, 8.67; N, 19.62; O, 12.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
UNC6641; UNC 6641; UNC-6641;
IUPAC/Chemical Name
(S)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-(N6-glycylglycyl-L-valyl-N2-isopropyl-N2-phenethyl-L-lysyl-L-lysyl)pyrrolidine-2-carboxamide
InChi Key
YKOIXRDPLTWEFE-WAGJPQHASA-N
InChi Code
InChI=1S/C49H86N14O8/c1-31(2)28-37(44(67)58-35(43(52)66)19-14-25-56-49(53)54)60-46(69)39-21-15-26-63(39)48(71)36(18-10-12-23-50)59-45(68)38(62(33(5)6)27-22-34-16-8-7-9-17-34)20-11-13-24-55-47(70)42(32(3)4)61-41(65)30-57-40(64)29-51/h7-9,16-17,31-33,35-39,42H,10-15,18-30,50-51H2,1-6H3,(H2,52,66)(H,55,70)(H,57,64)(H,58,67)(H,59,68)(H,60,69)(H,61,65)(H4,53,54,56)/t35-,36-,37-,38-,39-,42-/m0/s1
SMILES Code
O=C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)[C@H](CCCCNC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)N(CCC2=CC=CC=C2)C(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 999.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Engelberg IA, Liu J, Norris-Drouin JL, Cholensky SH, Ottavi SA, Frye SV, Kutateladze TG, James LI. Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). J Med Chem. 2021 Jun 24;64(12):8510-8522. doi: 10.1021/acs.jmedchem.1c00430. Epub 2021 May 17. PMID: 33999620; PMCID: PMC8225578.