Uncinatone | CAS#99624-92-7 | cytotoxin

MedKoo Cat#: 585345 | Name: Uncinatone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Uncinatone, from the roots of Clerodendrum bungei, exhibits moderate cytotoxicity, inhibits cell proliferation, and induces cell-cycle G(2)/M phase arrest.

Chemical Structure

Uncinatone

CAS#99624-92-7

Theoretical Analysis

MedKoo Cat#: 585345

Name: Uncinatone

CAS#: 99624-92-7

Chemical Formula: C20H22O4

Exact Mass: 326.1518

Molecular Weight: 326.39

Elemental Analysis: C, 73.60; H, 6.79; O, 19.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Uncinatone

IUPAC/Chemical Name

(9S,11bS)-7,11-dihydroxy-3,4,9,11b-tetramethyl-1,2,8,9-tetrahydronaphtho[2,1-f][1]benzofuran-6-one

InChi Key

IQGPVLVWUUPQMQ-FVINQWEUSA-N

InChi Code

InChI=1S/C20H22O4/c1-9-5-6-20(4)13(11(9)3)8-14(21)15-16(20)18(23)19-12(17(15)22)7-10(2)24-19/h8,10,22-23H,5-7H2,1-4H3/t10-,20-/m0/s1

SMILES Code

O=C1C=C2C(C)=C(C)CC[C@]2(C)C3=C(O)C4=C(C(O)=C31)C[C@H](C)O4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 326.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yue JR, Feng DQ, Xu YK. A new triterpenoid bearing octacosanoate from the stems and roots of Clerodendrum philippinum var. simplex (Verbenaceae). Nat Prod Res. 2015;29(13):1228-34. doi: 10.1080/14786419.2015.1023725. Epub 2015 Mar 23. PubMed PMID: 25801582. 2: Liu S, Zhu H, Zhang S, Zhang X, Yu Q, Xuan L. Abietane diterpenoids from Clerodendrum bungei. J Nat Prod. 2008 May;71(5):755-9. doi: 10.1021/np0703489. Epub 2008 Mar 19. PubMed PMID: 18348535. 3: Xu MF, Jia OY, Wang SJ, Zhu Q. A new bioactive diterpenoid from pestalotiopsis adusta, an endophytic fungus from clerodendrum canescens. Nat Prod Res. 2016 Dec;30(23):2642-2647. doi: 10.1080/14786419.2016.1138297. Epub 2016 Feb 2. PubMed PMID: 30919698. 4: Xu MF, Jia OY, Wang SJ, Zhu Q. A new bioactive diterpenoid from pestalotiopsis adusta, an endophytic fungus from clerodendrum canescens. Nat Prod Res. 2016 Feb 2:1-6. [Epub ahead of print] PubMed PMID: 26831947. 5: Zhu YK, Hu Y, Cheng N, Cen YZ. [Study on the chemical constituents of Clerodendron philippinum var. simplex]. Zhong Yao Cai. 2013 Jan;36(1):67-9. Chinese. PubMed PMID: 23750413. 6: Kim SK, Cho SB, Moon HI. Anti-complement activity of isolated compounds from the roots of Clerodendrum bungei Steud. Phytother Res. 2010 Nov;24(11):1720-3. doi: 10.1002/ptr.3254. PubMed PMID: 20648692. 7: Costa-Lotufo LV, Silveira ER, Barros MC, Lima MA, De Moraes ME, De Moraes MO, Pessoa C. Antiproliferative effects of abietane diterpenes from Aegiphila lhotzkyana. Planta Med. 2004 Feb;70(2):180-2. PubMed PMID: 14994200.