LY272015 | 5-HT2BR antagonist | CAS#159730-07-1

MedKoo Cat#: 128185 | Name: LY272015

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY272015 is a 5-HT2BR antagonist.

Chemical Structure

LY272015

CAS#159730-07-1

Theoretical Analysis

MedKoo Cat#: 128185

Name: LY272015

CAS#: 159730-07-1

Chemical Formula: C21H24N2O2

Exact Mass: 336.1838

Molecular Weight: 336.44

Elemental Analysis: C, 74.97; H, 7.19; N, 8.33; O, 9.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY272015; LY-272015; LY 272015

IUPAC/Chemical Name

1-(3,4-dimethoxybenzyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

InChi Key

GDAJGLDMCDMPIR-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H24N2O2/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3

SMILES Code

CC1=CC2=C(C=C1)NC3=C2CCNC3CC4=CC(=C(C=C4)OC)OC

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. Am J Physiol. 1999 Mar;276(3):H944-52. doi: 10.1152/ajpheart.1999.276.3.H944. PMID: 10070078. 2. Naito K, Tanaka C, Mitsuhashi M, Moteki H, Kimura M, Natsume H, Ogihara M. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biol Pharm Bull. 2016;39(1):121-9. doi: 10.1248/bpb.b15-00735. Epub 2015 Nov 14. PMID: 26567725.