Aminacrine hydrochloride monohydrate | CAS# 52417-22-8 | Biochemical

MedKoo Cat#: 573868 | Name: Aminacrine hydrochloride monohydrate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aminacrine is a highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.

Chemical Structure

Aminacrine hydrochloride monohydrate

CAS#52417-22-8 (HCl hydrate)

Theoretical Analysis

MedKoo Cat#: 573868

Name: Aminacrine hydrochloride monohydrate

CAS#: 52417-22-8 (HCl hydrate)

Chemical Formula: C13H13ClN2O

Exact Mass: 0.0000

Molecular Weight: 248.71

Elemental Analysis: C, 62.78; H, 5.27; Cl, 14.25; N, 11.26; O, 6.43

Price and Availability

Size	Price	Availability	Quantity
5g	USD 350.00	2 Weeks

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Related CAS #

90-45-9 (free base) 134-50-9 (HCl) 52417-22-8 (HCl hydrate) 25332-08-5 (pyruvate) 17162-18-4 (undecylate)

Synonym

Aminacrine hydrochloride monohydrate, Aminacrine HCl monohydrate

IUPAC/Chemical Name

9-Aminoacridine hydrochloride monohydrate

InChi Key

OREJEGKBQBIJSJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H10N2.ClH.H2O/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;;/h1-8H,(H2,14,15);1H;1H2

SMILES Code

NC1=C(C=CC=C2)C2=NC3=CC=CC=C31.[H]Cl.[H]O[H]

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 248.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cerón-Carrasco JP, Ruiz J, Vicente C, de Haro C, Bautista D, Zúñiga J, Requena A. DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III), and Ir(III) Antitumoral Complexes and Their Interaction with DNA. J Chem Theory Comput. 2017 Aug 8;13(8):3898-3910. doi: 10.1021/acs.jctc.7b00139. Epub 2017 Jul 6. PubMed PMID: 28641006. 2: Ishigami-Yuasa M, Watanabe Y, Mori T, Masuno H, Fujii S, Kikuchi E, Uchida S, Kagechika H. Development of WNK signaling inhibitors as a new class of antihypertensive drugs. Bioorg Med Chem. 2017 Jul 15;25(14):3845-3852. doi: 10.1016/j.bmc.2017.05.034. Epub 2017 May 19. PubMed PMID: 28566208. 3: Xiao S, Wang T, Ma X, Qin Y, Li X, Zhao Z, Liu X, Wang X, Xie H, Jiang Q, Sun L, Luo B, Shang L, Chen W, Bai Y, Tang M, He M, Wu L, Ma Q, Hou D, He J. Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial. Age Ageing. 2017 Sep 1;46(5):767-773. doi: 10.1093/ageing/afx045. PubMed PMID: 28419192. 4: Zhou D, Guo S, Zhang M, Liu Y, Chen T, Li Z. Mass spectrometry imaging of small molecules in biological tissues using graphene oxide as a matrix. Anal Chim Acta. 2017 Apr 15;962:52-59. doi: 10.1016/j.aca.2017.01.043. Epub 2017 Jan 31. PubMed PMID: 28231880. 5: Campbell AP, Wakelin LP, Denny WA, Finch AM. Homobivalent Conjugation Increases the Allosteric Effect of 9-aminoacridine at the α1-Adrenergic Receptors. Mol Pharmacol. 2017 Feb;91(2):135-144. doi: 10.1124/mol.116.105874. Epub 2016 Nov 30. PubMed PMID: 27903755. 6: Kava HW, Murray V. CpG methylation increases the DNA binding of 9-aminoacridine carboxamide Pt analogues. Bioorg Med Chem. 2016 Oct 1;24(19):4701-4710. doi: 10.1016/j.bmc.2016.08.011. Epub 2016 Aug 8. PubMed PMID: 27567075.