Synonym
NSC 13000; NSC-13000; NSC13000; 9-Aminoacridine, 9-Acridinylamine, Aminacrine
IUPAC/Chemical Name
9-Acridinamine
InChi Key
XJGFWWJLMVZSIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
SMILES Code
NC1=C(C=CC=C2)C2=NC3=CC=CC=C31
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
194.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhou Q, You C, Zheng C, Gu Y, Gu H, Zhang R, Wu H, Sun B. 3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents. Life Sci. 2018 Aug 1;206:1-9. doi: 10.1016/j.lfs.2018.05.010. Epub 2018 May 5. PubMed PMID: 29738780.
2: Loddo R, Francesconi V, Laurini E, Boccardo S, Aulic S, Fermeglia M, Pricl S, Tonelli M. 9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp). Bioorg Med Chem. 2018 Feb 15;26(4):855-868. doi: 10.1016/j.bmc.2018.01.001. Epub 2018 Jan 4. PubMed PMID: 29325885.
3: Solomon VR, Pundir S, Le HT, Lee H. Design and synthesis of novel quinacrine-[1,3]-thiazinan-4-one hybrids for their anti-breast cancer activity. Eur J Med Chem. 2018 Jan 1;143:1028-1038. doi: 10.1016/j.ejmech.2017.11.097. PubMed PMID: 29232580.
4: Solomon VR, Almnayan D, Lee H. Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad. Eur J Med Chem. 2017 Sep 8;137:156-166. doi: 10.1016/j.ejmech.2017.05.052. Epub 2017 May 27. PubMed PMID: 28586716.
