LA2 | CAS#N/A | pan-activator

MedKoo Cat#: 565787 | Name: LA2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LA2 is a novel pan-activator for all ampk isoforms

Chemical Structure

LA2

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565787

Name: LA2

CAS#: N/A

Chemical Formula: C31H30ClN5O5

Exact Mass: 587.1935

Molecular Weight: 588.06

Elemental Analysis: C, 63.32; H, 5.14; Cl, 6.03; N, 11.91; O, 13.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LA2; LA 2; LA-2

IUPAC/Chemical Name

(3R,3aR,6R,6aR)-6-((6-chloro-5-(4'-(4-(2-hydroxy-2-methylpropyl)-1H-pyrazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

InChi Key

QDOCWPJIJINJJM-CDRKEARJSA-N

InChi Code

InChI=1S/C31H30ClN5O5/c1-31(2,39)12-17-13-33-37(14-17)21-9-7-19(8-10-21)18-3-5-20(6-4-18)26-22(32)11-23-29(35-26)36-30(34-23)42-25-16-41-27-24(38)15-40-28(25)27/h3-11,13-14,24-25,27-28,38-39H,12,15-16H2,1-2H3,(H,34,35,36)/t24-,25-,27-,28-/m1/s1

SMILES Code

O[C@H]1[C@](OC[C@H]2OC3=NC4=NC(C5=CC=C(C6=CC=C(N7N=CC(CC(C)(O)C)=C7)C=C6)C=C5)=C(Cl)C=C4N3)([H])[C@]2([H])OC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 588.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Independent Control of the Magnetization in Ferromagnetic La2/3Sr1/3MnO3/SrTiO3/LaCoO3 Heterostructures Achieved by Epitaxial Lattice Mismatch. Nano Lett. 2016 Mar 9;16(3):1736-40. doi: 10.1021/acs.nanolett.5b04657. Epub 2016 Feb 2. PubMed PMID: 26822394. 5: Bao L, Chen M, Pan C, Yamaguchi T, Kato T, Olmstead MM, Balch AL, Akasaka T, Lu X. Crystallographic Evidence for Direct Metal-Metal Bonding in a Stable Open-Shell La2 @Ih -C80 Derivative. Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4242-6. doi: 10.1002/anie.201511930. Epub 2016 Feb 25. PubMed PMID: 26918907. 6: Haruta N, Sato T, Tanaka K. Reactivity of endohedral metallofullerene la2@c80 in nucleophilic and electrophilic attacks: vibronic coupling density approach. J Org Chem. 2015 Jan 2;80(1):141-7. doi: 10.1021/jo502208t. Epub 2014 Dec 1. PubMed PMID: 25389657. 7: Yi D, Liu J, Hsu SL, Zhang L, Choi Y, Kim JW, Chen Z, Clarkson JD, Serrao CR, Arenholz E, Ryan PJ, Xu H, Birgeneau RJ, Ramesh R. Atomic-scale control of magnetic anisotropy via novel spin-orbit coupling effect in La2/3Sr1/3MnO3/SrIrO3 superlattices. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6397-402. doi: 10.1073/pnas.1524689113. Epub 2016 May 19. PubMed PMID: 27199482; PubMed Central PMCID: PMC4988617. 8: Zhou W, Xiong Y, Zhang Z, Wang D, Tan W, Cao Q, Qian Z, Du Y. Multilevel Resistance Switching Memory in La2/3Ba1/3MnO3/0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (011) Heterostructure by Combined Straintronics-Spintronics. ACS Appl Mater Interfaces. 2016 Mar 2;8(8):5424-31. doi: 10.1021/acsami.5b11392. Epub 2016 Feb 16. PubMed PMID: 26846130. 9: Liu X, Hou W, Yang X, Shen Q. Pure-phase La2(WO4)3:Eu3+ nanocrystals and spindle-like NaLa(WO4)2:Yb3+/Er3+ nano/microcrystals: selective synthesis, morphologies and photoluminescent properties. Dalton Trans. 2013 Aug 28;42(32):11445-54. doi: 10.1039/c3dt50562f. Epub 2013 Jul 3. PubMed PMID: 23824277. 10: Yao L, Majumdar S, Äkäslompolo L, Inkinen S, Qin QH, van Dijken S. Electron-beam-induced Perovskite-Brownmillerite-Perovskite structural phase transitions in epitaxial La2/3Sr1/3MnO3 films. Adv Mater. 2014 May;26(18):2789-93. doi: 10.1002/adma.201305656. Epub 2014 Feb 19. PubMed PMID: 24554587. 11: Li ZW, Drees Y, Kuo CY, Guo H, Ricci A, Lamago D, Sobolev O, Rütt U, Gutowski O, Pi TW, Piovano A, Schmidt W, Mogare K, Hu Z, Tjeng LH, Komarek AC. Incommensurate spin correlations in highly oxidized cobaltates La2-xSrxCoO4. Sci Rep. 2016 Apr 27;6:25117. doi: 10.1038/srep25117. PubMed PMID: 27117928; PubMed Central PMCID: PMC4846828. 12: Xiong YQ, Zhou WP, Li Q, Cao QQ, Tang T, Wang DH, Du YW. Electric field modification of magnetism in Au/La2/3Ba1/3MnO3/Pt device. Sci Rep. 2015 Aug 4;5:12766. doi: 10.1038/srep12766. PubMed PMID: 26238932; PubMed Central PMCID: PMC4523834. 13: Suzuki M, Mizorogi N, Yang T, Uhlik F, Slanina Z, Zhao X, Yamada M, Maeda Y, Hasegawa T, Nagase S, Lu X, Akasaka T. 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