Synonym
Carnegine (free base); UNII-EOW70A27WK
IUPAC/Chemical Name
COc1cc2CCN(C)C(C)c2cc1OC
InChi Key
HRSIPKSSEVRSPG-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19NO2/c1-9-11-8-13(16-4)12(15-3)7-10(11)5-6-14(9)2/h7-9H,5-6H2,1-4H3
SMILES Code
COc1c(OC)cc2c(CCN(C2C)C)c1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
221.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Bembenek ME, Abell CW, Chrisey LA, Rozwadowska MD, Gessner W, Brossi A. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. doi: 10.1021/jm00163a025. PMID: 2296014.
6: El-Shazly A, Wink M. Tetrahydroisoquinoline and beta-carboline alkaloids from Haloxylon articulatum (Cav.) Bunge (Chenopodiaceae). Z Naturforsch C J Biosci. 2003 Jul-Aug;58(7-8):477-80. doi: 10.1515/znc-2003-7-805. PMID: 12939030.
7: Danielson PB, Frank MR, Fogleman JC. Comparison of larval and adult P-450 activity levels for alkaloid metabolism in desertDrosophila. J Chem Ecol. 1994 Aug;20(8):1893-906. doi: 10.1007/BF02066231. PMID: 24242717.
8: Erhardt PA, Soine TO. Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes. J Pharm Sci. 1975 Jan;64(1):53-62. doi: 10.1002/jps.2600640110. PMID: 124343.
9: Naghaway JA, Soine TO. Hofmann elimination with diazomethane on curare bases and selected quaternary tetrahydroisoquinoline alkaloids. J Pharm Sci. 1978 Apr;67(4):473-7. doi: 10.1002/jps.2600670408. PMID: 641751.
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