IRI-514 | CAS#147489-65-4 | synthetic thymopentin analogue

MedKoo Cat#: 145285 | Name: IRI-514

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IRI-514 is a synthetic analogue of thymopentin. IRI-514 has a long-lasting modulatory effect on behavioral responses to a stressor, and suggest that thymopoietin-derived peptides may have a role in modulating both behavioral and neuroendocrine responses to stress.

Chemical Structure

IRI-514

CAS#147489-65-4

Theoretical Analysis

MedKoo Cat#: 145285

Name: IRI-514

CAS#: 147489-65-4

Chemical Formula: C31H45N9O8

Exact Mass: 671.3391

Molecular Weight: 671.76

Elemental Analysis: C, 55.43; H, 6.75; M, 18.77; O, 19.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IRI-514; IRI514; IRI 514;

IUPAC/Chemical Name

(S)-3-((S)-1-(acetyl-L-arginyl)pyrrolidine-2-carboxamido)-4-((S)-2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-oxobutanoic acid

InChi Key

FMBHHLGHCVSGTR-LSBAASHUSA-N

InChi Code

1S/C31H45N9O8/c1-18(41)36-20(10-5-13-35-31(33)34)29(47)39-14-6-12-24(39)28(46)38-22(17-25(42)43)30(48)40-15-7-11-23(40)27(45)37-21(26(32)44)16-19-8-3-2-4-9-19/h2-4,8-9,20-24H,5-7,10-17H2,1H3,(H2,32,44)(H,36,41)(H,37,45)(H,38,46)(H,42,43)(H4,33,34,35)/t20-,21-,22-,23-,24-/m0/s1

SMILES Code

CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(N)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 671.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Menzaghi F, Heinrichs SC, Vargas-Cortes M, Goldstein G, Koob GF. IRI-514, a synthetic peptide analogue of thymopentin, reduces the behavioral response to social stress in rats. Physiol Behav. 1996 Aug;60(2):397-401. PMID: 8840897. 2: Crowther J, Adusumalli V, Mukherjee T, Jordan K, Abuaf P, Corkum N, Goldstein G, Tolan J. Determination of nanogram levels of peptide drug in rabbit and human plasma using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry. Anal Chem. 1994 Jul 15;66(14):2356-61. doi: 10.1021/ac00086a022. PMID: 8080108.