MedKoo Cat#: 565589 | Name: GI-530159 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GI-530159 is a selective dual trek1 and trek2 channel activator

Chemical Structure

GI-530159 HCl
GI-530159 HCl
CAS#GI-530159 HCl

Theoretical Analysis

MedKoo Cat#: 565589

Name: GI-530159 HCl

CAS#: GI-530159 HCl

Chemical Formula: C27H24Cl4F6N2O2

Exact Mass: 518.1429

Molecular Weight: 664.29

Elemental Analysis: Chemical Formula: C27H24Cl4F6N2O2 Exact Mass: 662.0496 Molecular Weight: 664.2914 Elemental Analysis: C, 48.82; H, 3.64; Cl, 21.35; F, 17.16; N, 4.22; O, 4.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
GI-530159; GI 530159; GI530159; GI-530159 HCl; GI-530159 hydrochloride; GI-530159 tetrahydrochloride
IUPAC/Chemical Name
4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine] tetrahydrochloride
InChi Key
BFXHILRIOVXRIO-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H20F6N2O2.4ClH/c28-26(29,30)25(27(31,32)33,17-1-9-21(10-2-17)36-23-13-5-19(34)6-14-23)18-3-11-22(12-4-18)37-24-15-7-20(35)8-16-24;;;;/h1-16H,34-35H2;4*1H
SMILES Code
FC(C(C1=CC=C(OC2=CC=C(N)C=C2)C=C1)(C3=CC=C(OC4=CC=C(N)C=C4)C=C3)C(F)(F)F)(F)F.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 664.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Loucif AJC, Saintot PP, Liu J, Antonio BM, Zellmer SG, Yoger K, Veale EL, Wilbrey A, Omoto K, Cao L, Gutteridge A, Castle NA, Stevens EB, Mathie A. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K(2P) ) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018 Jun;175(12):2272-2283. doi: 10.1111/bph.14098. Epub 2017 Dec 29. PubMed PMID: 29150838; PubMed Central PMCID: PMC5980259.