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MedKoo Cat#: 565426 | Name: PUMAi HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.

Chemical Structure

PUMAi HCl
PUMAi HCl
CAS#470695-03-5 (2HCl)

Theoretical Analysis

MedKoo Cat#: 565426

Name: PUMAi HCl

CAS#: 470695-03-5 (2HCl)

Chemical Formula: C19H28Cl2N2O3

Exact Mass:

Molecular Weight: 403.34

Elemental Analysis: C, 56.58; H, 7.00; Cl, 17.58; N, 6.95; O, 11.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
499985-87-4 (free base) 470695-03-5 (2HCl) 1164471-69-5 (HCl) 1352829-62-9 (R-isomer)
Synonym
PUMAi; PUMAi HCl; PUMAi hydrochloride;
IUPAC/Chemical Name
1-[4-(2-Hydroxyethyl)-1-piperazinyl]-3-(2-naphthyloxy)-2-propanol dihydrochloride
InChi Key
BYEYELUOZVKLDE-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H26N2O3.2ClH/c22-12-11-20-7-9-21(10-8-20)14-18(23)15-24-19-6-5-16-3-1-2-4-17(16)13-19;;/h1-6,13,18,22-23H,7-12,14-15H2;2*1H
SMILES Code
OC(COC1=CC=C2C=CC=CC2=C1)CN3CCN(CCO)CC3.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 403.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018 Feb 7;10(427). pii: eaam7610. doi: 10.1126/scitranslmed.aam7610. PubMed PMID: 29437148; PubMed Central PMCID: PMC5827930. 2: Mercado-Flores Y, Trejo-Aguilar A, Ramírez-Zavala B, Villa-Tanaca L, Hernández-Rodríguez C. Purification and characterization of an intracellular aspartyl acid proteinase (pumAi) from Ustilago maydis. Can J Microbiol. 2005 Feb;51(2):171-5. PubMed PMID: 16091776. 3: Mercado-Flores Y, Hernández-Rodríguez C, Ruiz-Herrera J, Villa-Tanaca L. Proteinases and exopeptidases from the phytopathogenic fungus Ustilago maydis. Mycologia. 2003 Mar-Apr;95(2):327-39. PubMed PMID: 21156619.