Synonym
Panidazole; BRN0533483; BRN-0533483; BRN 0533483
IUPAC/Chemical Name
4-(2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)pyridine (9CI)
InChi Key
ARYPMCPJIWUCIP-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12N4O2/c1-9-13-8-11(15(16)17)14(9)7-4-10-2-5-12-6-3-10/h2-3,5-6,8H,4,7H2,1H3
SMILES Code
O=[N+](C1=CN=C(C)N1CCC2=CC=NC=C2)[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
232.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Voogd CE, van der Stel JJ, van Bruchem MC. Increased mutagenicity of some nitroimidazoles by non-mutagenic nitrotoluene on Klebsiella pneumoniae (fluctuation test). Mutat Res. 1992 Jun;282(2):73-7. doi: 10.1016/0165-7992(92)90077-u. PMID: 1377354.
2: Treviño García-Manzo N. Amibiasis. Tratamiento médico. Hay algo mejor que el metronidazol? [Amebiasis. Medical treatment. Is there anything better than metronidazole?]. Rev Gastroenterol Mex. 1989 Jul-Sep;54(3):181-4. Spanish. PMID: 2682974.
3: Boreham PF, Phillips RE, Shepherd RW. A comparison of the in-vitro activity of some 5-nitroimidazoles and other compounds against Giardia intestinalis. J Antimicrob Chemother. 1985 Nov;16(5):589-95. doi: 10.1093/jac/16.5.589. PMID: 4077772.
4: Jokipii L, Jokipii AM. Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group. Antimicrob Agents Chemother. 1985 Oct;28(4):561-4. doi: 10.1128/AAC.28.4.561. PMID: 4073879; PMCID: PMC180305.
5: Voogd CE, Van der Stel JJ, Jacobs JJ. The mutagenic action of nitroimidazoles. II. Tinidazole, ipronidazole, panidazole and ornidazole. Mutat Res. 1977 Apr;48(2):155-61. doi: 10.1016/0027-5107(77)90155-5. PMID: 327306.
6: Botero D, Perez A. Treatment of intestinal amoebiasis and vaginal trichomoniasis with panidazole and its comparison with metronidazole. Trans R Soc Trop Med Hyg. 1977;71(6):508-11. doi: 10.1016/0035-9203(77)90145-6. PMID: 343312.
7: Shapero M, Jefferies HS, Ryan DM. Laboratory evaluation of panidazole (1-(2'-( -pyridyl) ethyl-2-methyl)-5-nitroimidazole), a new amoebicide. Ann Trop Med Parasitol. 1972 Jun;66(2):187-92. doi: 10.1080/00034983.1972.11686815. PMID: 4338871.
8: Pickholz S, Shapero M, Ryan DM, Jefferies HS, Warren BT. 1-(2-(gamma- pyridyl)ethyl)-2-methyl-5-nitro-imidazole (panidazole), a new amoebicide. Experientia. 1970 Sep 26;26(9):1025. doi: 10.1007/BF02114176. PMID: 5478615.
