MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 565382 | Name: DT204

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DT204 is a SCFSkp2 inhibitor which blocks Skp2 binding to Cullin-1 and Commd1, thereby synergistically enhancing BTZ-induced apoptosis and stabilization. DT204 also increases p27 levels.

Chemical Structure

DT204
DT204
CAS#428497-71-6

Theoretical Analysis

MedKoo Cat#: 565382

Name: DT204

CAS#: 428497-71-6

Chemical Formula: C19H13BrClNO5S

Exact Mass: 480.9386

Molecular Weight: 482.73

Elemental Analysis: C, 47.27; H, 2.71; Br, 16.55; Cl, 7.34; N, 2.90; O, 16.57; S, 6.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
DT-204; DT 204; DT204
IUPAC/Chemical Name
(4-Bromo-2-{(Z)-[3-(4-chlorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)acetic acid
InChi Key
GWNJSDGJHRSQFT-PXNMLYILSA-N
InChi Code
InChI=1S/C19H13BrClNO5S/c20-13-3-6-15(27-10-17(23)24)12(7-13)8-16-18(25)22(19(26)28-16)9-11-1-4-14(21)5-2-11/h1-8H,9-10H2,(H,23,24)/b16-8-
SMILES Code
O=C(O)COC1=CC=C(Br)C=C1/C=C(SC(N2CC3=CC=C(Cl)C=C3)=O)/C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 482.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Malek E, Abdel-Malek MA, Jagannathan S, Vad N, Karns R, Jegga AG, Broyl A, van Duin M, Sonneveld P, Cottini F, Anderson KC, Driscoll JJ. Pharmacogenomics and chemical library screens reveal a novel SCF(SKP2) inhibitor that overcomes Bortezomib resistance in multiple myeloma. Leukemia. 2017 Mar;31(3):645-653. doi: 10.1038/leu.2016.258. Epub 2016 Sep 28. PubMed PMID: 27677741; PubMed Central PMCID: PMC5339431. 2: Giraud E, Baucheron S, Virlogeux-Payant I, Nishino K, Cloeckaert A. Effects of natural mutations in the ramRA locus on invasiveness of epidemic fluoroquinolone-resistant Salmonella enterica serovar Typhimurium isolates. J Infect Dis. 2013 Mar 1;207(5):794-802. doi: 10.1093/infdis/jis755. Epub 2012 Dec 10. PubMed PMID: 23230062. 3: Abouzeed YM, Baucheron S, Cloeckaert A. ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2008 Jul;52(7):2428-34. doi: 10.1128/AAC.00084-08. Epub 2008 Apr 28. PubMed PMID: 18443112; PubMed Central PMCID: PMC2443889. 4: Rabsch W. Salmonella typhimurium phage typing for pathogens. Methods Mol Biol. 2007;394:177-211. doi: 10.1007/978-1-59745-512-1_10. PubMed PMID: 18363237. 5: Pelludat C, Prager R, Tschäpe H, Rabsch W, Schuchhardt J, Hardt WD. Pilot study to evaluate microarray hybridization as a tool for Salmonella enterica serovar Typhimurium strain differentiation. J Clin Microbiol. 2005 Aug;43(8):4092-106. PubMed PMID: 16081956; PubMed Central PMCID: PMC1233888. 6: Baucheron S, Mouline C, Praud K, Chaslus-Dancla E, Cloeckaert A. TolC but not AcrB is essential for multidrug-resistant Salmonella enterica serotype Typhimurium colonization of chicks. J Antimicrob Chemother. 2005 May;55(5):707-12. Epub 2005 Apr 6. PubMed PMID: 15814604. 7: Olliver A, Vallé M, Chaslus-Dancla E, Cloeckaert A. Overexpression of the multidrug efflux operon acrEF by insertional activation with IS1 or IS10 elements in Salmonella enterica serovar typhimurium DT204 acrB mutants selected with fluoroquinolones. Antimicrob Agents Chemother. 2005 Jan;49(1):289-301. PubMed PMID: 15616308; PubMed Central PMCID: PMC538886. 8: Andrews-Polymenis HL, Rabsch W, Porwollik S, McClelland M, Rosetti C, Adams LG, Bäumler AJ. Host restriction of Salmonella enterica serotype Typhimurium pigeon isolates does not correlate with loss of discrete genes. J Bacteriol. 2004 May;186(9):2619-28. PubMed PMID: 15090502; PubMed Central PMCID: PMC387805. 9: Baucheron S, Chaslus-Dancla E, Cloeckaert A. Role of TolC and parC mutation in high-level fluoroquinolone resistance in Salmonella enterica serotype Typhimurium DT204. J Antimicrob Chemother. 2004 Apr;53(4):657-9. Epub 2004 Feb 25. PubMed PMID: 14985270. 10: Pelludat C, Mirold S, Hardt WD. The SopEPhi phage integrates into the ssrA gene of Salmonella enterica serovar Typhimurium A36 and is closely related to the Fels-2 prophage. J Bacteriol. 2003 Sep;185(17):5182-91. PubMed PMID: 12923091; PubMed Central PMCID: PMC181011. 11: Baucheron S, Imberechts H, Chaslus-Dancla E, Cloeckaert A. The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204. Microb Drug Resist. 2002 Winter;8(4):281-9. PubMed PMID: 12523625. 12: Rabsch W, Mirold S, Hardt WD, Tschäpe H. The dual role of wild phages for horizontal gene transfer among Salmonella strains. Berl Munch Tierarztl Wochenschr. 2002 Sep-Oct;115(9-10):355-9. PubMed PMID: 12357672.

View History

Upenazime

Upenazime

UCSF678

UCSF678

UI-EP002

UI-EP002