IUPAC/Chemical Name
2-bromo-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide
InChi Key
KXLZSKTVZMRRCY-RBUKOAKNSA-N
InChi Code
InChI=1S/C20H40BrNO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(24)18(17-23)22-20(25)16-21/h18-19,23-24H,2-17H2,1H3,(H,22,25)/t18-,19+/m0/s1
SMILES Code
BrCC(N[C@H]([C@H](O)CCCCCCCCCCCCCCC)CO)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
422.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Ordóñez YF, Abad JL, Aseeri M, Casas J, Garcia V, Casasampere M, Schuchman EH, Levade T, Delgado A, Triola G, Fabrias G. Activity-Based Imaging of Acid Ceramidase in Living Cells. J Am Chem Soc. 2019 May 15;141(19):7736-7742. doi: 10.1021/jacs.8b11687. Epub 2019 May 2. PMID: 31030513.
Muley H, Dowdy T, Zaibaq F, Karadimov G, Li A, Song H, Zhang M, Zhang W, Wong Z, Zhang L, Lita A, Larion M. Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors. bioRxiv [Preprint]. 2024 Apr 29:2024.04.27.591426. doi: 10.1101/2024.04.27.591426. PMID: 38903086; PMCID: PMC11188094.
