DSM265 is a long-duration, potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor. DSM265 is potential useful for the prevention and treatment of malaria. DSM265 is the first DHODH inhibitor to reach clinical development for treatment of malaria. DSM265 is highly selective toward DHODH of the malaria parasite Plasmodium, efficacious against both blood and liver stages of P. falciparum, and active against drug-resistant parasite isolates. DSM265 has advantages over current treatment options that are dosed daily or are inactive against the parasite liver stage.
MedKoo Cat#: 206459
Name: DSM265
CAS#: 1282041-94-4
Chemical Formula: C14H12F7N5S
Exact Mass: 415.0702
Molecular Weight: 415.33
Elemental Analysis: C, 40.49; H, 2.91; F, 32.02; N, 16.86; S, 7.72
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.0 | 120.39 |
The following data is based on the product molecular weight 415.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
