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MedKoo Cat#: 555543 | Name: SPL‑410

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SPL‑410 is a potent, orally active SPPL2a Inhibitor with IC50 = 9 nM. SPL-410 inhibited in vivo CD74/p8 fragment processing in mice at 10 mg/kg oral dose.

Chemical Structure

SPL‑410
SPL‑410
CAS#2351886-00-3

Theoretical Analysis

MedKoo Cat#: 555543

Name: SPL‑410

CAS#: 2351886-00-3

Chemical Formula: C24H31F3N2O4S

Exact Mass: 500.1957

Molecular Weight: 500.58

Elemental Analysis: C, 57.59; H, 6.24; F, 11.39; N, 5.60; O, 12.78; S, 6.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2351886-00-3
Synonym
SPL‑410; SPL 410; SPL410;
IUPAC/Chemical Name
N-((2S,3S)-3-Amino-2-hydroxy-3-(4-(trifluoromethoxy)phenyl)propyl)-4-(tert-butyl)-N-cyclobutylbenzenesulfonamide
InChi Key
KEEHEUGOPCFXAV-VXKWHMMOSA-N
InChi Code
InChI=1S/C24H31F3N2O4S/c1-23(2,3)17-9-13-20(14-10-17)34(31,32)29(18-5-4-6-18)15-21(30)22(28)16-7-11-19(12-8-16)33-24(25,26)27/h7-14,18,21-22,30H,4-6,15,28H2,1-3H3/t21-,22-/m0/s1
SMILES Code
O=S(C1=CC=C(C(C)(C)C)C=C1)(N(C[C@H](O)[C@@H](N)C2=CC=C(OC(F)(F)F)C=C2)C3CCC3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
SPPL2a (Signal Peptide Peptidase Like 2a) is an intramembrane aspartyl protease engaged in the function of B-cells and dendritic cells.

Preparing Stock Solutions

The following data is based on the product molecular weight 500.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors Juraj Velcicky*Casey J. N. MathisonVictor NikulinDaniel PfliegerRobert EppleMihai AzimioaraChristopher CowPierre-Yves MichellysPascal RigollierDaniel R. BeisnerUrsula BodendorfDanilo GueriniBo LiuBen WenSamantha ZaharevitzTrixi Brandl ACS Medicinal Chemistry Letters, Articles ASAP (As Soon As Publishable)