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MedKoo Cat#: 565243 | Name: DB1255

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DB1255 is a ERG/DNA binding inhibitor which targets the DNA-binding activity of the human ERG transcription factor.

Chemical Structure

DB1255
DB1255
CAS#915978-94-8 (free base)

Theoretical Analysis

MedKoo Cat#: 565243

Name: DB1255

CAS#: 915978-94-8 (free base)

Chemical Formula: C22H18N4S2

Exact Mass: 402.0973

Molecular Weight: 402.53

Elemental Analysis: C, 65.64; H, 4.51; N, 13.92; S, 15.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
915978-94-8 (free base) 1417897-13-2 (HCl)
Synonym
DB-1255; DB 1255; DB1255
IUPAC/Chemical Name
4,4'-([2,2'-Bithiophene]-5,5'-diyl)dibenzimidamide; 4,4'-(2,2'-Bithiene-5,5'-diyl)dibenzenecarboximidamide
InChi Key
RARVJIWPKRBECK-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H18N4S2/c23-21(24)15-5-1-13(2-6-15)17-9-11-19(27-17)20-12-10-18(28-20)14-3-7-16(8-4-14)22(25)26/h1-12H,(H3,23,24)(H3,25,26)
SMILES Code
N=C(N)C1=CC=C(C2=CC=C(C3=CC=C(C4=CC=C(C=C4)C(N)=N)S3)S2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Munde M, Kumar A, Peixoto P, Depauw S, Ismail MA, Farahat AA, Paul A, Say MV, David-Cordonnier MH, Boykin DW, Wilson WD. The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine. Biochemistry. 2014 Feb 25;53(7):1218-27. doi: 10.1021/bi401582t. Epub 2014 Feb 13. PubMed PMID: 24495039; PubMed Central PMCID: PMC3985535. 2: Nhili R, Peixoto P, Depauw S, Flajollet S, Dezitter X, Munde MM, Ismail MA, Kumar A, Farahat AA, Stephens CE, Duterque-Coquillaud M, David Wilson W, Boykin DW, David-Cordonnier MH. Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nucleic Acids Res. 2013 Jan 7;41(1):125-38. doi: 10.1093/nar/gks971. Epub 2012 Oct 23. PubMed PMID: 23093599; PubMed Central PMCID: PMC3592449.