MedKoo Cat#: 526968 | Name: ND-336 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ND-336 is a novel highly selective inhibitor of gelatinases (MMP-2 and MMP-9) and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition. ND-336 holds considerable promise in healing of diabetic wounds.

Chemical Structure

ND-336 hydrochloride
ND-336 hydrochloride
CAS#1807453-83-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 526968

Name: ND-336 hydrochloride

CAS#: 1807453-83-3 (HCl)

Chemical Formula: C16H18ClNO3S2

Exact Mass:

Molecular Weight: 371.89

Elemental Analysis: C, 51.67; H, 4.88; Cl, 9.53; N, 3.77; O, 12.91; S, 17.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1807453-71-9 (free base) 1807453-83-3 (HCl)
Synonym
ND-336; ND 336; ND336; ND-336 hydrochloride; ND-336 HCl,
IUPAC/Chemical Name
(4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenyl)methanamine hydrochloride
InChi Key
DRGIZFGSEKSFIC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17NO3S2.ClH/c17-9-12-1-3-13(4-2-12)20-14-5-7-16(8-6-14)22(18,19)11-15-10-21-15;/h1-8,15H,9-11,17H2;1H
SMILES Code
NCC(C=C1)=CC=C1OC2=CC=C(S(CC3SC3)(=O)=O)C=C2.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 371.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chang M. Restructuring of the extracellular matrix in diabetic wounds and healing: A perspective. Pharmacol Res. 2016 May;107:243-8. doi: 10.1016/j.phrs.2016.03.008. PubMed PMID: 27033051. 2: Jiang ZL, Sun YC, Wang ZB, Liang ZB, Ren K, Xie ZL, Zhang M, Liao Y. [Variation Characteristics and Sources of Polycyclic Aromatic Hydrocarbons in Karst Subterranean River During Rainfall Events]. Huan Jing Ke Xue. 2015 Nov;36(11):4088-94. Chinese. PubMed PMID: 26910994. 3: Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15226-31. doi: 10.1073/pnas.1517847112. PubMed PMID: 26598687; PubMed Central PMCID: PMC4679041.