MedKoo Cat#: 573536 | Name: AT-7519M
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AT-7519M is a small molecule inhibitor of cyclin-dependent kinases 1, 2, 4, 5, and 9 with in vitro activity against lymphoid malignancies.

Chemical Structure

AT-7519M
AT-7519M
CAS#902135-89-1(methanesulfonate)

Theoretical Analysis

MedKoo Cat#: 573536

Name: AT-7519M

CAS#: 902135-89-1(methanesulfonate)

Chemical Formula: C17H21Cl2N5O5S

Exact Mass: 477.0640

Molecular Weight: 478.35

Elemental Analysis: C, 42.69; H, 4.43; Cl, 14.82; N, 14.64; O, 16.72; S, 6.70

Price and Availability

Size Price Availability Quantity
10mg USD 285.00 2 Weeks
50mg USD 650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
AT-7519M; AT7519M; AT 7519M; AT7519 methanesulfonate
IUPAC/Chemical Name
4-((2,6-Dichlorobenzoyl)amino)-n-piperidin-4-yl-1H-pyrazole-3-carboxamide methanesulfonate
InChi Key
UELIMKCXGLIYCY-UHFFFAOYSA-N
InChi Code
1S/C16H17Cl2N5O2.CH4O3S/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;1-5(2,3)4/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H3,(H,2,3,4)
SMILES Code
CS(=O)(=O)O.c1cc(c(c(c1)Cl)C(=O)Nc2c[nH]nc2C(=O)NC3CCNCC3)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 478.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roskoski R Jr. Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs. Pharmacol Res. 2019 Jan;139:471-488. doi: 10.1016/j.phrs.2018.11.035. Epub 2018 Nov 30. Review. PubMed PMID: 30508677. 2: Seftel MD, Kuruvilla J, Kouroukis T, Banerji V, Fraser G, Crump M, Kumar R, Chalchal HI, Salim M, Laister RC, Crocker S, Gibson SB, Toguchi M, Lyons JF, Xu H, Powers J, Sederias J, Seymour L, Hay AE. The CDK inhibitor AT7519M in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. A Phase II study of the Canadian Cancer Trials Group. Leuk Lymphoma. 2017 Jun;58(6):1358-1365. doi: 10.1080/10428194.2016.1239259. Epub 2016 Oct 17. PubMed PMID: 27750483.