IBPR002 | CAS# 1192754-38-3 | Aurora Kinase Inhibitor

MedKoo Cat#: 565055 | Name: IBPR002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IBPR002 is an aurora kinase inhibitor which reveals mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.

Chemical Structure

IBPR002

CAS#1192754-38-3

Theoretical Analysis

MedKoo Cat#: 565055

Name: IBPR002

CAS#: 1192754-38-3

Chemical Formula: C34H36N6O4

Exact Mass: 592.2798

Molecular Weight: 592.70

Elemental Analysis: C, 68.90; H, 6.12; N, 14.18; O, 10.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IBPR-002; IBPR 002; IBPR002

IUPAC/Chemical Name

1-{4-[2-(6-{4-[2-(4-Hydroxy-piperidin-1-yl)-ethoxy]-phenyl}-furo[2,3-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-phenyl-urea

InChi Key

WEVRAOPLGYJTLY-UHFFFAOYSA-N

InChi Code

InChI=1S/C34H36N6O4/c41-28-15-18-40(19-16-28)20-21-43-29-12-8-25(9-13-29)31-22-30-32(36-23-37-33(30)44-31)35-17-14-24-6-10-27(11-7-24)39-34(42)38-26-4-2-1-3-5-26/h1-13,22-23,28,41H,14-21H2,(H,35,36,37)(H2,38,39,42)

SMILES Code

O=C(NC1=CC=CC=C1)NC2=CC=C(CCNC3=C4C(OC(C5=CC=C(OCCN6CCC(O)CC6)C=C5)=C4)=NC=N3)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 592.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wu JM, Chen CT, Coumar MS, Lin WH, Chen ZJ, Hsu JT, Peng YH, Shiao HY, Lin WH, Chu CY, Wu JS, Lin CT, Chen CP, Hsueh CC, Chang KY, Kao LP, Huang CY, Chao YS, Wu SY, Hsieh HP, Chi YH. Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1779-87. doi: 10.1073/pnas.1220523110. Epub 2013 Apr 22. PubMed PMID: 23610398; PubMed Central PMCID: PMC3651446.