HI-101 | HIF-1 inhibitor

MedKoo Cat#: 128239 | Name: HI-101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HI-101 is a HIF-1 inhibitor. HI-101 has an adamantaniline moiety, and can effectively reduce HIF-1α protein expression.

Chemical Structure

HI-101

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128239

Name: HI-101

CAS#: N/A

Chemical Formula: C23H24ClNO

Exact Mass: 365.1546

Molecular Weight: 365.90

Elemental Analysis: C, 75.50; H, 6.61; Cl, 9.69; N, 3.83; O, 4.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HI-101; HI 101; HI101

IUPAC/Chemical Name

N-(4-(adamantan-1-yl)phenyl)-3-chlorobenzamide

InChi Key

ZDKYMTGIPNVMCE-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H24ClNO/c24-20-3-1-2-18(11-20)22(26)25-21-6-4-19(5-7-21)23-12-15-8-16(13-23)10-17(9-15)14-23/h1-7,11,15-17H,8-10,12-14H2,(H,25,26)

SMILES Code

O=C(C1=CC=CC(Cl)=C1)NC2=CC=C(C=C2)C34CC5CC(CC(C5)C4)C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 365.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li H, Liu Y, Xue Z, Zhang L, Ruan X, Yang J, Fan Z, Zhao H, Cao Y, Chen G, Xu Y, Zhou L. Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor-1α. Adv Sci (Weinh). 2023 Sep;10(25):e2301071. doi: 10.1002/advs.202301071. Epub 2023 Jul 3. PMID: 37401167; PMCID: PMC10477886. 2: Hou P, Pi Y, Jiao Z, Tian X, Hu W, Zhang Y, Zhao Y, Wang F. Association of Body Composition with Pulmonary Function in Ningxia: The China Northwest Cohort. Diabetes Metab Syndr Obes. 2022 Oct 25;15:3243-3254. doi: 10.2147/DMSO.S383098. PMID: 36304482; PMCID: PMC9594934. 3: Ghosh D, Damodaran KK. Analysing the role of anions in the synthesis of catalytically active urea-based MOFs. Dalton Trans. 2022 Nov 1;51(42):16316-16324. doi: 10.1039/d2dt02421g. PMID: 36222369. 4: Miao J, Feng S, Dou S, Ma Y, Yang L, Yan L, Yu P, Wu Y, Ye T, Wen B, Lu P, Li S, Guo Y. Association between mercury exposure and lung function in young adults: A prospective cohort study in Shandong, China. Sci Total Environ. 2023 Jun 20;878:162759. doi: 10.1016/j.scitotenv.2023.162759. Epub 2023 Mar 11. PMID: 36907407. 5: Jahan I, Begum M, Akhter S, Islam MZ, Jahan N, Haque M. Effects of alternate nostril breathing exercise on respiratory functions in healthy young adults leading stressful lifestyle. J Popul Ther Clin Pharmacol. 2020 Mar 19;27(1):e104-e114. doi: 10.15586/jptcp.v27i1.668. PMID: 32320171.