MedKoo Cat#: 526079 | Name: A-350619 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A-350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC).

Chemical Structure

A-350619 hydrochloride
A-350619 hydrochloride
CAS#1217201-17-6

Theoretical Analysis

MedKoo Cat#: 526079

Name: A-350619 hydrochloride

CAS#: 1217201-17-6

Chemical Formula: C21H26Cl2N2OS

Exact Mass: 424.1143

Molecular Weight: 425.41

Elemental Analysis: C, 59.29; H, 6.16; Cl, 16.67; N, 6.59; O, 3.76; S, 7.54

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Synonym
A-350619 hydrochloride
IUPAC/Chemical Name
3-[2-(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride
InChi Key
PDVBHWZPRQFKJS-KYIGKLDSSA-N
InChi Code
InChI=1S/C21H25ClN2OS.ClH/c1-24(2)16-6-5-15-23-21(25)14-9-17-7-3-4-8-20(17)26-19-12-10-18(22)11-13-19;/h3-4,7-14H,5-6,15-16H2,1-2H3,(H,23,25);1H/b14-9+;
SMILES Code
O=C(NCCCCN(C)C)/C=C/C1=CC=CC=C1SC2=CC=C(Cl)C=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 425.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kotzki S, Roustit M, Arnaud C, Boutonnat J, Blaise S, Godin-Ribuot D, Cracowski JL. Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J Pharmacol Exp Ther. 2013 Sep;346(3):424-31. doi: 10.1124/jpet.113.205484. Epub 2013 Jul 9. PubMed PMID: 23838678.